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神経膠腫の multiplicity の発生機序に関する検討 : p53 geneのcodon 72 polymorphism 検出法を用いて
https://sapmed.repo.nii.ac.jp/records/8068
https://sapmed.repo.nii.ac.jp/records/8068952f13ca-2a33-4352-b1bc-07ecfb308e57
名前 / ファイル | ライセンス | アクション |
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n134057647123.pdf (2.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-03-24 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 神経膠腫の multiplicity の発生機序に関する検討 : p53 geneのcodon 72 polymorphism 検出法を用いて | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | multiplicity | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | P53gene | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | LOH | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | codon72 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
岡, 亨治
× 岡, 亨治× 伊東, 民雄× 堀田, 隆史× 猿田, 武× 奥村, 智吉× 西谷, 幹雄× 中村, 順一× 末松, 克美 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Mechanism of multiplicity in the glial tumor is still unknown. The p53 gene has been impliceted as a tumor suppressor gene and abnormality of this gene has been reported in many human glial tumors. Codon 72 polymorphism in the p53 gene can be detected by digestion of polymerase chain reaction-amplified DNA using allele-specific restriction endonuclease (PCR-RFLP). We analyzed the DNA from the tissue in the two separated enhanced lesions of Gd-MRI in the same patient using this PCR-RFLP method and detected loss of the same allele of the p53 gene in each enhanced area. This result suggests there is a possibility that the two separated lesions originated from same progenitor cell and the multiplicity of this case resulted from metastatic mechanism. | |||||
書誌情報 |
北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation 巻 7, 号 1, p. 23-27, 発行日 1994-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1340-5764 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | Examination of mechanism of multiplicity in the glial tumor using detection of codon 72 poly-morphism in the p53 gene | |||||
出版者 | ||||||
出版者 | 中村記念病院 |