@article{oai:sapmed.repo.nii.ac.jp:00008068,
 author = {岡, 亨治 and 伊東, 民雄 and 堀田, 隆史 and 猿田, 武 and 奥村, 智吉 and 西谷, 幹雄 and 中村, 順一 and 末松, 克美},
 issue = {1},
 journal = {北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation},
 month = {Dec},
 note = {Mechanism of multiplicity in the glial tumor is still unknown. The p53 gene has been impliceted as a tumor suppressor gene and abnormality of this gene has been reported in many human glial tumors. Codon 72 polymorphism in the p53 gene can be detected by digestion of polymerase chain reaction-amplified DNA using allele-specific restriction endonuclease (PCR-RFLP). We analyzed the DNA from the tissue in the two separated enhanced lesions of Gd-MRI in the same patient using this PCR-RFLP method and detected loss of the same allele of the p53 gene in each enhanced area. This result suggests there is a possibility that the two separated lesions originated from same progenitor cell and the multiplicity of this case resulted from metastatic mechanism.},
 pages = {23--27},
 title = {神経膠腫の multiplicity の発生機序に関する検討 : p53 geneのcodon 72 polymorphism 検出法を用いて},
 volume = {7},
 year = {1994}
}