| アイテムタイプ |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2019-08-26 |
| タイトル |
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|
タイトル |
Cardiac troponin I and perioperative factors in pediatric open heart surgery |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aortic cross-clamp |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
cardiopulmonary bypass |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
congenital heart disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
open heart surgery |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
troponin |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
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|
ID登録 |
10.15114/smj.87.25 |
|
ID登録タイプ |
JaLC |
| 著者 |
Tsutomu, WADA
Masato, YOKOZAWA
Motoki, TAKAMURO
Dai, ARAKI
Norihiko, EBUOKA
Junichi, OHBA
Tsuyoshi, TACHIBANA
Mitsuru, MORI
Hiroyuki, TSUTSUMI
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Troponin I (TnI) are highly specific to the myocardium, and measurement of the plasma TnI levels has been widely used to evaluate myocardial damage. This study was performed to ascertain the pathologic or perioperative variables that are significantly associated with the plasma cardiac TnI level. We also intended to provide reference range of TnI elevation after uncomplicated pediatric open heart surgery.Methods: One hundred fifty-one patients undergoing repair of atrial septal defects (ASDs) (n = 61), ventricular septal defects (VSDs) (n = 71), tetralogy of Fallot (TOF) (n = 14), or complete atrioventricular septal defects (CAVSDs) (n = 5) were included. The plasma TnI level was measured prior to surgery, on days 1 and 7 postoperatively. We analyzed the relationship between the TnI level and pathology, cardiopulmonary bypass, and other perioperative actors.Results: All patients underwent uncomplicated surgery and postoperative course. With all pathologies, the plasma TnI level peaked on postoperative day 1 and rapidly declined. The TnI level on postoperative day 1 was higher in VSD than ASD, and there was a further rise in TOF and CAVSD but no significant difference between them. The TnI level on postoperative day 1 was strongly correlated with the operative time, cardiopulmonary bypass time, and aortic cross-clamp (ACC) time. Multiple linear regression analysis showed that the operative time, ACC time, lowest rectal temperature, TOF lesion, and inotropic support period could influence the TnI level.Conclusions: Elevation of plasma TnI after pediatric open heart surgery for various congenital heart diseases is mainly associated with the condition of cardiopulmonary bypass (operative and ACC times) and is not affected with surgical procedures expect for ventricular muscle resection during repair of TOF. Level of TnI elevation confirmed in the study could provide reference range in uncomplicated open heart surgery for each four pathologies. (298 words) |
|
言語 |
en |
| 書誌情報 |
札幌医学雑誌 = The Sapporo Medical Journal
en : The Sapporo medical journal
巻 87,
号 1-6,
p. 25-33,
発行日 2018-12-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0036-472X |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
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出版者 |
札幌医科大学医学部 |
0036472x8725.pdf (716.4 kB)
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