{"created":"2023-05-15T09:08:01.249238+00:00","id":15485,"links":{},"metadata":{"_buckets":{"deposit":"0754d306-e9bd-455f-b285-5d9a2ddc12b1"},"_deposit":{"created_by":14,"id":"15485","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"15485"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00015485","sets":["1658:1659:2063"]},"author_link":[],"control_number":"15485","item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-6","bibliographicPageEnd":"33","bibliographicPageStart":"25","bibliographicVolumeNumber":"87","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo Medical Journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Troponin I (TnI) are highly specific to the myocardium, and measurement of the plasma TnI levels has been widely used to evaluate myocardial damage. This study was performed to ascertain the pathologic or perioperative variables that are significantly associated with the plasma cardiac TnI level. We also intended to provide reference range of TnI elevation after uncomplicated pediatric open heart surgery.Methods: One hundred fifty-one patients undergoing repair of atrial septal defects (ASDs) (n = 61), ventricular septal defects (VSDs) (n = 71), tetralogy of Fallot (TOF) (n = 14), or complete atrioventricular septal defects (CAVSDs) (n = 5) were included. The plasma TnI level was measured prior to surgery, on days 1 and 7 postoperatively. We analyzed the relationship between the TnI level and pathology, cardiopulmonary bypass, and other perioperative actors.Results: All patients underwent uncomplicated surgery and postoperative course. With all pathologies, the plasma TnI level peaked on postoperative day 1 and rapidly declined. The TnI level on postoperative day 1 was higher in VSD than ASD, and there was a further rise in TOF and CAVSD but no significant difference between them. The TnI level on postoperative day 1 was strongly correlated with the operative time, cardiopulmonary bypass time, and aortic cross-clamp (ACC) time. Multiple linear regression analysis showed that the operative time, ACC time, lowest rectal temperature, TOF lesion, and inotropic support period could influence the TnI level.Conclusions: Elevation of plasma TnI after pediatric open heart surgery for various congenital heart diseases is mainly associated with the condition of cardiopulmonary bypass (operative and ACC times) and is not affected with surgical procedures expect for ventricular muscle resection during repair of TOF. Level of TnI elevation confirmed in the study could provide reference range in uncomplicated open heart surgery for each four pathologies. (298 words)","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.87.25","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsutomu, WADA"}]},{"creatorNames":[{"creatorName":"Masato, YOKOZAWA"}]},{"creatorNames":[{"creatorName":"Motoki, TAKAMURO"}]},{"creatorNames":[{"creatorName":"Dai, ARAKI"}]},{"creatorNames":[{"creatorName":"Norihiko, EBUOKA"}]},{"creatorNames":[{"creatorName":"Junichi, OHBA"}]},{"creatorNames":[{"creatorName":"Tsuyoshi, TACHIBANA"}]},{"creatorNames":[{"creatorName":"Mitsuru, MORI"}]},{"creatorNames":[{"creatorName":"Hiroyuki, TSUTSUMI"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-26"}],"displaytype":"detail","filename":"0036472x8725.pdf","filesize":[{"value":"716.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"0036472x8725.pdf","url":"https://sapmed.repo.nii.ac.jp/record/15485/files/0036472x8725.pdf"},"version_id":"a52a9c97-fe82-4616-9db9-d246a88d20cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aortic cross-clamp","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiopulmonary bypass","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital heart disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"open heart surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"troponin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cardiac troponin I and perioperative factors in pediatric open heart surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cardiac troponin I and perioperative factors in pediatric open heart surgery","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["2063"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-26"},"publish_date":"2019-08-26","publish_status":"0","recid":"15485","relation_version_is_last":true,"title":["Cardiac troponin I and perioperative factors in pediatric open heart surgery"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T05:03:06.473638+00:00"}