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胃粘膜内フィプロネクチン関連物質に関する免疫組織学的研究 : ラット・エタノール胃潰瘍モデルについて
https://doi.org/10.15114/smj.58.379
https://doi.org/10.15114/smj.58.379657455f5-9574-429a-99d9-134fea87deb6
名前 / ファイル | ライセンス | アクション |
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n0036472X586379.pdf (5.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-08-16 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 胃粘膜内フィプロネクチン関連物質に関する免疫組織学的研究 : ラット・エタノール胃潰瘍モデルについて | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Immunohistological Study on a Fibronectin-related Substance in the Gastric Fundic Mucosa : On an Ethanol-induced Gastric Ulcer Model of the Rat | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Fibronectin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Gastric mucosa | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ethanol-induced gastric ulcer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Prostaglandin E? | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cysteamine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.58.379 | |||||
ID登録タイプ | JaLC | |||||
著者 |
陳, 家傲
× 陳, 家傲× 矢花, 剛 |
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著者別名 | ||||||
姓名 | Chen, Jia-ao | |||||
著者別名 | ||||||
姓名 | Yabana, Tsuyoshi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The pathogenetic role of fibronectin-related substance (FNRS), which was immunohistologically identified mainly in the lower portion of the gastric fundic mucosa, was studied using an ethanol (EtOH)-induced gastric ulcer model of the rat. Macroscopic and microscopic changes occurred in the gastric mucosa immediately (usually within 5 minutes) and developed time-dependently after the ingestion of 100% EtOH. The FNRS in the fundic mucosa decreased similarly and time-dependently and could be hardly detected 60 minutes after the ingestion of 100% EtOH. The ulcer index(UI) increased and inversely the FNRS score decreased time-dependently, showing a mirror-image manner. 20% EtOH did not cause visible mucosal alterations, but the FNRS decreased with time. The latter changes, however, were observed to a lesser degree than those in both 50% and 100% EtOH groups. These gastric mucosal lesions, which were adjudged from macroscopic and histological changes, developed in a concentration-dependent manner for EtOH. The changes in UI and FNRS score appeared to show a mirror image. Pretreatment with either cimetidine (30 and 50 mg/kg, i. v.), 11(R), 16, 16-trimethyl prostaglandin E2 (tmPGE2; 10 and 50 μg/kg, p. o.) or sulfhydryl cysteamine (50 and 200 mg/kg, s. c. i.) significantly prevented macroscopic and microscopic changes in the gastric mucosa which were induced 60 minutes after the ingestion of 50% EtOH. These drugs significantly decreased the UI but increased the FNRS score, dose-dependently. These results indicate that the FNRS located in the lower portion of the fundic mucosa, in which acid and pepsin are actively secreted, plays a protective role in the pathogenesis of the EtOH-induced gastric ulcer of the rat. It is also suggested that the FNRS may be mediated by H2 receptor and/or endogenous PG. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 58, 号 6, p. 379-390, 発行日 1989-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |