{"created":"2023-05-15T09:07:27.428236+00:00","id":14831,"links":{},"metadata":{"_buckets":{"deposit":"e56396de-9750-4ee9-bd55-f55008f7008f"},"_deposit":{"created_by":14,"id":"14831","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14831"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014831","sets":["1658:1659:1720"]},"author_link":["26378","26379","26376","26377"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"390","bibliographicPageStart":"379","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The pathogenetic role of fibronectin-related substance （FNRS）, which was immunohistologically identified mainly in the lower portion of the gastric fundic mucosa, was studied using an ethanol （EtOH）-induced gastric ulcer model of the rat. Macroscopic and microscopic changes occurred in the gastric mucosa immediately （usually within 5 minutes） and developed time-dependently after the ingestion of 100% EtOH. The FNRS in the fundic mucosa decreased similarly and time-dependently and could be hardly detected 60 minutes after the ingestion of 100% EtOH. The ulcer index（UI） increased and inversely the FNRS score decreased time-dependently, showing a mirror-image manner. 20% EtOH did not cause visible mucosal alterations, but the FNRS decreased with time. The latter changes, however, were observed to a lesser degree than those in both 50% and 100% EtOH groups. These gastric mucosal lesions, which were adjudged from macroscopic and histological changes, developed in a concentration-dependent manner for EtOH. The changes in UI and FNRS score appeared to show a mirror image. Pretreatment with either cimetidine （30 and 50 mg/kg, i. v.）, 11（R）, 16, 16-trimethyl prostaglandin E2 （tmPGE2; 10 and 50 μg/kg, p. o.） or sulfhydryl cysteamine （50 and 200 mg/kg, s. c. i.） significantly prevented macroscopic and microscopic changes in the gastric mucosa which were induced 60 minutes after the ingestion of 50% EtOH. These drugs significantly decreased the UI but increased the FNRS score, dose-dependently. These results indicate that the FNRS located in the lower portion of the fundic mucosa, in which acid and pepsin are actively secreted, plays a protective role in the pathogenesis of the EtOH-induced gastric ulcer of the rat. It is also suggested that the FNRS may be mediated by H2 receptor and/or endogenous PG.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26378","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Chen, Jia-ao"}]},{"nameIdentifiers":[{"nameIdentifier":"26379","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yabana, Tsuyoshi"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.58.379","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"陳, 家傲"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢花, 剛"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X586379.pdf","filesize":[{"value":"5.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X586379.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14831/files/n0036472X586379.pdf"},"version_id":"8612a55d-5bba-4afe-9bb6-7b34b16ea0a2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fibronectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric mucosa","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ethanol-induced gastric ulcer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostaglandin E?","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cysteamine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胃粘膜内フィプロネクチン関連物質に関する免疫組織学的研究 : ラット・エタノール胃潰瘍モデルについて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃粘膜内フィプロネクチン関連物質に関する免疫組織学的研究 : ラット・エタノール胃潰瘍モデルについて","subitem_title_language":"ja"},{"subitem_title":"Immunohistological Study on a Fibronectin-related Substance in the Gastric Fundic Mucosa : On an Ethanol-induced Gastric Ulcer Model of the Rat","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14831","relation_version_is_last":true,"title":["胃粘膜内フィプロネクチン関連物質に関する免疫組織学的研究 : ラット・エタノール胃潰瘍モデルについて"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:10.649642+00:00"}