WEKO3
アイテム
{"_buckets": {"deposit": "d996d339-9f95-4a64-ac17-f85e1ee50b84"}, "_deposit": {"created_by": 14, "id": "14710", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "14710"}, "status": "published"}, "_oai": {"id": "oai:sapmed.repo.nii.ac.jp:00014710", "sets": ["1722"]}, "author_link": ["25843", "25844", "25841", "25842"], "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-04-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "137", "bibliographicPageStart": "127", "bibliographicVolumeNumber": "60", "bibliographic_titles": [{"bibliographic_title": "札幌医学雑誌 = The Sapporo medical journal"}, {"bibliographic_title": "The Sapporo medical journal", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The expression of cell surface ICAM-1 antigen and ICAM-1 mRNA in cell lines of hematopoietic diseases was investigated. In addition, the concentration of solubilized ICAM-1 antigen in spent medium of cell lines and hi sera of patients suffering from hematopoietic diseases was detected using an ELISA system established by us. The results are summarized as follows : 1. The level of cell surface ICAM-1 expression in cell lines of hematopoietic diseases was high in B-cell lines and especially high in myeloma cell lines. On the other hand, the level was low in T-een lines and myeloid cell lines, except for ATL cell lines, which showed high level expression. 2. In the investigation of ICAM-1 mRNA expression, the level was parallel to that of cell surface antigen. 3. The expression of cell surface ICAM-1 antigen increased in all lineages with IFN-γ treatment, and the rate of increase was highest in T-cell lines. 4. The concentration of solubilized ICAM-1 antigen in spent medium of cell lines was parallel to the expression level of cell surface antigen. 5. The concentration of ICAM-1 antigen in sera of patients suffering from hematopoietic diseases was high in B-cell leukemia. In cases of B-cell type malignant lymphoma, the concentration was high in cases of advanced stage and/or in cases with leukemic change. As to T-cell malig-nancies, the concentration of serum ICAM-1 was high in cases of T-CLL, ATL and nasal T-cell lymphoma. The concentration was low in cases of myelocytic leukemia and multiple myeloma. 6. The clinical features associated with high level serum ICAM-1 antigen were hepatosplenomegaly, invasion of tumor cells into organs, tumor formation and poor prognosis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "25843", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakano, Tatsumi"}]}, {"nameIdentifiers": [{"nameIdentifier": "25844", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Imai, Kohzoh"}]}]}, "item_7_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.15114/smj.60.127", "subitem_identifier_reg_type": "JaLC"}]}, "item_7_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "札幌医科大学医学部"}]}, "item_7_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0036-472X", "subitem_source_identifier_type": "ISSN"}]}, "item_7_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "仲野, 龍己"}], "nameIdentifiers": [{"nameIdentifier": "25841", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今井, 浩三"}], "nameIdentifiers": [{"nameIdentifier": "25842", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-31"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "n0036472X602127.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "n0036472X602127.pdf", "url": "https://sapmed.repo.nii.ac.jp/record/14710/files/n0036472X602127.pdf"}, "version_id": "0d27325d-1145-47a3-b4fc-dfbc4834cb24"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ICAM-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hematopoietic disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Monoclonal antibody", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ICAM-1 mRNA", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出", "subitem_title_language": "ja"}, {"subitem_title": "Expression of ICAM-1 Molecule on the Surface of Hematopoietic Tumor Cells and Detection of ICAM-1 Antigen in Patient\u0027s Serum", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "14", "path": ["1722"], "permalink_uri": "https://doi.org/10.15114/smj.60.127", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-07-31"}, "publish_date": "2019-07-31", "publish_status": "0", "recid": "14710", "relation": {}, "relation_version_is_last": true, "title": ["造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出"], "weko_shared_id": -1}
造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出
https://doi.org/10.15114/smj.60.127
https://doi.org/10.15114/smj.60.12788443219-9f12-491c-84bc-b19334247fa5
名前 / ファイル | ライセンス | アクション |
---|---|---|
n0036472X602127.pdf (2.0 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of ICAM-1 Molecule on the Surface of Hematopoietic Tumor Cells and Detection of ICAM-1 Antigen in Patient's Serum | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ICAM-1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hematopoietic disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Monoclonal antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ICAM-1 mRNA | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.60.127 | |||||
ID登録タイプ | JaLC | |||||
著者 |
仲野, 龍己
× 仲野, 龍己× 今井, 浩三 |
|||||
著者別名 | ||||||
姓名 | Nakano, Tatsumi | |||||
著者別名 | ||||||
姓名 | Imai, Kohzoh | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The expression of cell surface ICAM-1 antigen and ICAM-1 mRNA in cell lines of hematopoietic diseases was investigated. In addition, the concentration of solubilized ICAM-1 antigen in spent medium of cell lines and hi sera of patients suffering from hematopoietic diseases was detected using an ELISA system established by us. The results are summarized as follows : 1. The level of cell surface ICAM-1 expression in cell lines of hematopoietic diseases was high in B-cell lines and especially high in myeloma cell lines. On the other hand, the level was low in T-een lines and myeloid cell lines, except for ATL cell lines, which showed high level expression. 2. In the investigation of ICAM-1 mRNA expression, the level was parallel to that of cell surface antigen. 3. The expression of cell surface ICAM-1 antigen increased in all lineages with IFN-γ treatment, and the rate of increase was highest in T-cell lines. 4. The concentration of solubilized ICAM-1 antigen in spent medium of cell lines was parallel to the expression level of cell surface antigen. 5. The concentration of ICAM-1 antigen in sera of patients suffering from hematopoietic diseases was high in B-cell leukemia. In cases of B-cell type malignant lymphoma, the concentration was high in cases of advanced stage and/or in cases with leukemic change. As to T-cell malig-nancies, the concentration of serum ICAM-1 was high in cases of T-CLL, ATL and nasal T-cell lymphoma. The concentration was low in cases of myelocytic leukemia and multiple myeloma. 6. The clinical features associated with high level serum ICAM-1 antigen were hepatosplenomegaly, invasion of tumor cells into organs, tumor formation and poor prognosis. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 60, 号 2, p. 127-137, 発行日 1991-04-01 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |