@article{oai:sapmed.repo.nii.ac.jp:00014710,
 author = {仲野, 龍己 and 今井, 浩三},
 issue = {2},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Apr},
 note = {The expression of cell surface ICAM-1 antigen and ICAM-1 mRNA in cell lines of hematopoietic diseases was investigated. In addition, the concentration of solubilized ICAM-1 antigen in spent medium of cell lines and hi sera of patients suffering from hematopoietic diseases was detected using an ELISA system established by us. The results are summarized as follows : 1. The level of cell surface ICAM-1 expression in cell lines of hematopoietic diseases was high in B-cell lines and especially high in myeloma cell lines. On the other hand, the level was low in T-een lines and myeloid cell lines, except for ATL cell lines, which showed high level expression. 2. In the investigation of ICAM-1 mRNA expression, the level was parallel to that of cell surface antigen. 3. The expression of cell surface ICAM-1 antigen increased in all lineages with IFN-γ treatment, and the rate of increase was highest in T-cell lines. 4. The concentration of solubilized ICAM-1 antigen in spent medium of cell lines was parallel to the expression level of cell surface antigen. 5. The concentration of ICAM-1 antigen in sera of patients suffering from hematopoietic diseases was high in B-cell leukemia. In cases of B-cell type malignant lymphoma, the concentration was high in cases of advanced stage and/or in cases with leukemic change. As to T-cell malig-nancies, the concentration of serum ICAM-1 was high in cases of T-CLL, ATL and nasal T-cell lymphoma. The concentration was low in cases of myelocytic leukemia and multiple myeloma. 6. The clinical features associated with high level serum ICAM-1 antigen were hepatosplenomegaly, invasion of tumor cells into organs, tumor formation and poor prognosis.},
 pages = {127--137},
 title = {造血器腫瘍細胞における細胞間接着分子ICAM-1の発現とその血中における検出},
 volume = {60},
 year = {1991}
}