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Suppression of Interferon-induced Oligo-2', 5'-adenylate Synthetase Induction in Human Hepatoma Cell Line, Li-7
https://doi.org/10.15114/tr.23.103
https://doi.org/10.15114/tr.23.10301794640-1f03-455f-a0cc-a02cf4f2507c
名前 / ファイル | ライセンス | アクション |
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n0041409323103.pdf (585.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
タイトル | Suppression of Interferon-induced Oligo-2', 5'-adenylate Synthetase Induction in Human Hepatoma Cell Line, Li-7 | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Interferon | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oligo-2' | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 5'-adenylate synthetase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hepatoma cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.23.103 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Fujii, Nobuhiro
× Fujii, Nobuhiro× Indoh, Tomokazu× Murakami, Tadayuki× Kimura, Kouichi× Oguma, Keiji× Tsukada, Yutaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Induction of oligo-2', 5'-adenylate synthetase (2-5AS) activity by interferon (IFN) was investigated in a human hepatoma cell line, Li-7 cells. Little induction of 2-5AS activity by IFN was demonstrated in Li-7 cells in comparison with other types of cell lines including Ramos, NC-37, FL, Co-3. Furthermore, failure to induce 2-5AS was much clearer in old-cultured cells. Cell growth inhibition by IFN was demonstrated in only high titers of IFN (>10? IU/ml), in which the enzyme had one hundred fold higher activity than that of untreated cells. Poor induction of 2-5AS was in part the result of some inhibitor presented in cellular extracts of Li-7 cells and the decreased level of 2-5AS mRNA transcription. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 23, p. 103-109, 発行日 1988 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |