{"created":"2023-05-15T09:07:03.591330+00:00","id":14286,"links":{},"metadata":{"_buckets":{"deposit":"b5e05def-aced-49c3-b084-234c61b1ddd5"},"_deposit":{"created_by":15,"id":"14286","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14286"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014286","sets":["1658:1661:1716"]},"author_link":["24069","24070","24071","24072","24073","24074"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"109","bibliographicPageStart":"103","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Tumor Research"},{"bibliographic_title":"Tumor Research","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Induction of oligo-2', 5'-adenylate synthetase (2-5AS) activity by interferon (IFN) was investigated in a human hepatoma cell line, Li-7 cells. Little induction of 2-5AS activity by IFN was demonstrated in Li-7 cells in comparison with other types of cell lines including Ramos, NC-37, FL, Co-3. Furthermore, failure to induce 2-5AS was much clearer in old-cultured cells. Cell growth inhibition by IFN was demonstrated in only high titers of IFN (>10? IU/ml), in which the enzyme had one hundred fold higher activity than that of untreated cells. Poor induction of 2-5AS was in part the result of some inhibitor presented in cellular extracts of Li-7 cells and the decreased level of 2-5AS mRNA transcription.","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/tr.23.103","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Sapporo Medical University"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0041-4093","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujii, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"24069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Indoh, Tomokazu"}],"nameIdentifiers":[{"nameIdentifier":"24070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Tadayuki"}],"nameIdentifiers":[{"nameIdentifier":"24071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"24072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oguma, Keiji"}],"nameIdentifiers":[{"nameIdentifier":"24073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukada, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"24074","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0041409323103.pdf","filesize":[{"value":"585.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0041409323103.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14286/files/n0041409323103.pdf"},"version_id":"65b222ee-19ca-46ff-8e85-d9e7af1ae92a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Interferon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oligo-2'","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"5'-adenylate synthetase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatoma cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Suppression of Interferon-induced Oligo-2', 5'-adenylate Synthetase Induction in Human Hepatoma Cell Line, Li-7","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of Interferon-induced Oligo-2', 5'-adenylate Synthetase Induction in Human Hepatoma Cell Line, Li-7","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1716"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14286","relation_version_is_last":true,"title":["Suppression of Interferon-induced Oligo-2', 5'-adenylate Synthetase Induction in Human Hepatoma Cell Line, Li-7"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:47:00.653717+00:00"}