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Biochemical Analysis of Cytokine Effect on the Glycosphingolipid Expression of Human Glioma Cell Lines
https://doi.org/10.15114/tr.28.9
https://doi.org/10.15114/tr.28.95d55551a-55e1-4326-a04d-eb4aa9aef974
名前 / ファイル | ライセンス | アクション |
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n00414093289.pdf (2.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
タイトル | Biochemical Analysis of Cytokine Effect on the Glycosphingolipid Expression of Human Glioma Cell Lines | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Glycosphingolipid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cytokine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Glioma | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.28.9 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Byung, OokChoi
× Byung, OokChoi× Yamaki, Toshiaki× Ibayashi, Yukihiro× Gasa, Shinsei× Hashi, Kazuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have already found that a human glioma cell line U118MG could modu-late glycosphingolipid (GSL) expression via certain cytokines, though this effect is changeable and very difficult to reproduce even under consistent culture condi-tions. Consecutive analysis of cytokine effect using other 6 glioma (A172, T98G, KG-1C, U87MG, U138MG and U373MG) and one melanoma cell line (Mewo) failed to detect any GSL modulation. A total of ten cytokines were used in this experiment : IL-1beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha, IFN-alpha, IFN-beta, IFN-gamma, and G-CSF, for treating KG-1C mixed glioma cells and 8 cytokines out of those for treating T98G glioblastoma cells. The rest of the cell lines were cultured with IFN-gamma and IL-4 because those two had once shown dramatic effect on GSL expression on U118MG cells. The fact that none of the 6 glioma cell lines responded to cytokines in terms of GSL modulation implies that cytokines do not play a significant role in regulating GSL expression in the glial cell lineage. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 28, p. 9-18, 発行日 1993 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |