{"created":"2023-05-15T09:07:01.999522+00:00","id":14254,"links":{},"metadata":{"_buckets":{"deposit":"741fd4e2-0fe0-4816-a411-a711b8577cd4"},"_deposit":{"created_by":15,"id":"14254","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"14254"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014254","sets":["1658:1661:1708"]},"author_link":["23889","23890","23891","23892","23893"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"18","bibliographicPageStart":"9","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Tumor Research"},{"bibliographic_title":"Tumor Research","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have already found that a human glioma cell line U118MG could modu-late glycosphingolipid (GSL) expression via certain cytokines, though this effect is changeable and very difficult to reproduce even under consistent culture condi-tions. Consecutive analysis of cytokine effect using other 6 glioma (A172, T98G, KG-1C, U87MG, U138MG and U373MG) and one melanoma cell line (Mewo) failed to detect any GSL modulation. A total of ten cytokines were used in this experiment : IL-1beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha, IFN-alpha, IFN-beta, IFN-gamma, and G-CSF, for treating KG-1C mixed glioma cells and 8 cytokines out of those for treating T98G glioblastoma cells. The rest of the cell lines were cultured with IFN-gamma and IL-4 because those two had once shown dramatic effect on GSL expression on U118MG cells. The fact that none of the 6 glioma cell lines responded to cytokines in terms of GSL modulation implies that cytokines do not play a significant role in regulating GSL expression in the glial cell lineage.","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/tr.28.9","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Sapporo Medical University"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0041-4093","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Byung, OokChoi"}],"nameIdentifiers":[{"nameIdentifier":"23889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaki, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"23890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ibayashi, Yukihiro"}],"nameIdentifiers":[{"nameIdentifier":"23891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Gasa, Shinsei"}],"nameIdentifiers":[{"nameIdentifier":"23892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashi, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"23893","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n00414093289.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n00414093289.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14254/files/n00414093289.pdf"},"version_id":"ee02a4e0-135c-42ae-8c89-c4d6a5cd8e6c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glycosphingolipid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Glioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Biochemical Analysis of Cytokine Effect on the Glycosphingolipid Expression of Human Glioma Cell Lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biochemical Analysis of Cytokine Effect on the Glycosphingolipid Expression of Human Glioma Cell Lines","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1708"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14254","relation_version_is_last":true,"title":["Biochemical Analysis of Cytokine Effect on the Glycosphingolipid Expression of Human Glioma Cell Lines"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:45:33.563268+00:00"}