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プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用
https://doi.org/10.15114/smj.78.1
https://doi.org/10.15114/smj.78.19e053c81-e07e-4e4b-b093-3d44acf840bc
名前 / ファイル | ライセンス | アクション |
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n0036472X7811.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Biomarker | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Proteomic approach | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Alzheimer’s disease | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Nerve injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Acute graft-versus-host disease | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.78.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
今井, 伸一
× 今井, 伸一× 木村, 成寿× 松本, 圭代× 相馬, 仁× 小海, 康夫 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A biomarker for a disease, which also called “pathologic marker”, is a biological substance for understanding quantitatively and objectively pathologic change of the disease. The pathologic marker is useful for a diagnosis and assessment of therapeutic effect of the disease. We study an identification of a biomarker for some diseases by proteomic approach using pathologic model system, bioprobe and mass spectrometer, and clinical application of its marker. Annexin A5, which was found in culture supernatant of amyloid β peptide-stimulated neuronal cells by proteomic approach, is a potential molecular candidate for the diagnosis of Alzheimer’s disease. Global expression profile of nerve injury also indicated an important protein profile during nerve regeneration. CCL8, which was found in plasma of an acute graft-versus-host disease (aGVHD)-model mouse, is a promising specific marker for aGVHD. | |||||
言語 | en | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 78, 号 1-6, p. 1-6, 発行日 2009 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |