@article{oai:sapmed.repo.nii.ac.jp:00014543,
 author = {今井, 伸一 and 木村, 成寿 and 松本, 圭代 and 相馬, 仁 and 小海, 康夫},
 issue = {1-6},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {},
 note = {A biomarker for a disease, which also called “pathologic marker”, is a biological substance for understanding quantitatively and objectively pathologic change of the disease. The pathologic marker is useful for a diagnosis and assessment of therapeutic effect of the disease. We study an identification of a biomarker for some diseases by proteomic approach using pathologic model system, bioprobe and mass spectrometer, and clinical application of its marker. Annexin A5, which was found in culture supernatant of amyloid β peptide-stimulated neuronal cells by proteomic approach, is a potential molecular candidate for the diagnosis of Alzheimer’s disease. Global expression profile of nerve injury also indicated an important protein profile during nerve regeneration. CCL8, which was found in plasma of an acute graft-versus-host disease (aGVHD)-model mouse, is a promising specific marker for aGVHD.},
 pages = {1--6},
 title = {プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用},
 volume = {78},
 year = {2009}
}