{"created":"2023-05-15T09:07:14.758165+00:00","id":14543,"links":{},"metadata":{"_buckets":{"deposit":"5a733490-65c9-440f-9145-e0d35e457262"},"_deposit":{"created_by":3,"id":"14543","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14543"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014543","sets":["1658:1659:1774"]},"author_link":["25082","25083","25084","25085","25086"],"control_number":"14543","item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-6","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A biomarker for a disease, which also called “pathologic marker”, is a biological substance for understanding quantitatively and objectively pathologic change of the disease. The pathologic marker is useful for a diagnosis and assessment of therapeutic effect of the disease. We study an identification of a biomarker for some diseases by proteomic approach using pathologic model system, bioprobe and mass spectrometer, and clinical application of its marker. Annexin A5, which was found in culture supernatant of amyloid β peptide-stimulated neuronal cells by proteomic approach, is a potential molecular candidate for the diagnosis of Alzheimer’s disease. Global expression profile of nerve injury also indicated an important protein profile during nerve regeneration. CCL8, which was found in plasma of an acute graft-versus-host disease (aGVHD)-model mouse, is a promising specific marker for aGVHD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.78.1","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今井, 伸一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村, 成寿"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 圭代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相馬, 仁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小海, 康夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0036472X7811.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X7811.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14543/files/n0036472X7811.pdf"},"version_id":"67b32c7e-6c77-4bcd-af84-b2c310b0fe00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Proteomic approach","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nerve injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Acute graft-versus-host disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用","subitem_title_language":"ja"}]},"item_type_id":"7","owner":"3","path":["1774"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14543","relation_version_is_last":true,"title":["プロテオミクスアプローチによる血漿バイオマーカーの同定と臨床応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-12-13T02:19:01.504477+00:00"}