Item type |
紀要論文 / Departmental Bulletin Paper(1) |
公開日 |
2019-07-31 |
タイトル |
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言語 |
en |
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タイトル |
Review : Clinical and Pathological Aspects of Cancer-Associated Retinopathy (CAR) |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
CAR |
キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
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主題 |
MAR |
キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
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主題 |
Recoverin |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
hsc 70 |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Autoimmunity |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
ID登録 |
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|
ID登録 |
10.15114/tr.33.1 |
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ID登録タイプ |
JaLC |
著者 |
Maeda, Akiko
Maeda, Tadao
Ogawa, Keiichi
Maruyama, Ikuyo
Nakagawa, Takashi
Ohguro, Hiroshi
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Cancer-associated retinopathy (CAR) is an ocular manifestation of para-neoplastic syndrome and is further classified into two distinct diseases, CAR and MAR (melanoma-associated retinopathy) . CAR is associated with epithe-lial cancers, mostly lung small cell carcinoma, and is characterized by retini-tis pigmentosa-like retinal degeneration, such as ring scotoma, night blind-ness, and lowering of a and b-waves in electroretinogram (ERG) . Usually CAR can be found before an underlying primary cancer is diagnosed. In con-trast, MAR is associated with cutaneous malignant melanoma and is characte-rized by the relatively sudden onset of photophobia, nyctalopia, and lowering of b-wave in ERG. Histopathological study has revealed that photoreceptor and bipolar degeneration are primarily involved in CAR and MAR, respec-tively. Both CAR and MAR are believed to result from an autoimmune basis. In CAR, a calcium binding protein called recoverin, heat shock cog-nate protein 70 (hsc 70) , and other proteins are identified as retinal autoanti-gens, while the retinal antigens in MAR have not yet been identified. In this text, we review up-to-date information about the clinical and pathological aspects of these diseases. |
書誌情報 |
Tumor Research
en : Tumor Research
巻 33,
p. 1-13,
発行日 1998
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ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0041-4093 |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
出版者 |
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出版者 |
Sapporo Medical University |