@article{oai:sapmed.repo.nii.ac.jp:00014213,
 author = {Maeda, Akiko and Maeda, Tadao and Ogawa, Keiichi and Maruyama, Ikuyo and Nakagawa, Takashi and Ohguro, Hiroshi},
 journal = {Tumor Research, Tumor Research},
 month = {},
 note = {Cancer-associated retinopathy (CAR) is an ocular manifestation of para-neoplastic syndrome and is further classified into two distinct diseases, CAR and MAR (melanoma-associated retinopathy) . CAR is associated with epithe-lial cancers, mostly lung small cell carcinoma, and is characterized by retini-tis pigmentosa-like retinal degeneration, such as ring scotoma, night blind-ness, and lowering of a and b-waves in electroretinogram (ERG) . Usually CAR can be found before an underlying primary cancer is diagnosed. In con-trast, MAR is associated with cutaneous malignant melanoma and is characte-rized by the relatively sudden onset of photophobia, nyctalopia, and lowering of b-wave in ERG. Histopathological study has revealed that photoreceptor and bipolar degeneration are primarily involved in CAR and MAR, respec-tively. Both CAR and MAR are believed to result from an autoimmune basis. In CAR, a calcium binding protein called recoverin, heat shock cog-nate protein 70 (hsc 70) , and other proteins are identified as retinal autoanti-gens, while the retinal antigens in MAR have not yet been identified. In this text, we review up-to-date information about the clinical and pathological aspects of these diseases.},
 pages = {1--13},
 title = {Review : Clinical and Pathological Aspects of Cancer-Associated Retinopathy (CAR)},
 volume = {33},
 year = {1998}
}