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Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma
https://doi.org/10.15114/smj.88.21
https://doi.org/10.15114/smj.88.2125299ba1-4225-45fb-be67-859bf67e4b8a
名前 / ファイル | ライセンス | アクション |
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0036472X88121.pdf (5.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-04-07 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of the anti-tumor mechanism of BRD4 inhibition in hepatocellular carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | hepatocellular carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | histone acetylation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | BRD4 | |||||
キーワード | ||||||
言語 | ja | |||||
主題Scheme | Other | |||||
主題 | JQ1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | BCAT1 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.88.21 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Hajime, SASAKI
× Hajime, SASAKI× Hiroshi, KITAJIMA× Takeshi, NIINUMA× Hideki, WAKASUGI× Kazuya, ISHIGURO× Akira, YOROZU× Gouta, SUDO× Tomo, HATAHIRA× Noriyuki, AKUTU× Eiichiro, YAMAMOTO× Masahiro, KAI× Shigeru, SASAKI× Hiroshi, NAKASE× Hiromu, SUZUKI |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Bromodomain and extra terminal (BET) family proteins, which include BRD4, are readers of histone acetyl-lysines and key regulators of gene transcription. BRD4 inhibitors exert anti-tumor effects in various cancers, including hepatocellular carcinoma (HCC). We investigated the mechanism underlying the antitumor effects of BRD4 inhibition in HCC. We first tested the effects of the BRD4 inhibitor JQ1 in a series of 9 HCC cell lines and found that it strongly suppressed HCC cell proliferation by inducing cell cycle arrest and apoptosis. Gene expression microarray analysis revealed that JQ1 also induced marked changes in the gene expression profiles of HCC cells, and genes associated with cell cycle and apoptosis were significantly enriched among the affected genes. Notably, a number of cancer-related genes, including BCAT1, DDR1, GDF15, FANCD2, SENP1 and TYRO3, were strongly suppressed by JQ1 in HCC cells. We also confirmed BRD4 bound within the promoter regions of these genes, which suggests they are targets of BRD4 in HCC cells. JQ1 thus appears to exert its anti-tumor effects in HCC by suppressing multiple BRD4 target genes. | |||||
書誌情報 |
札幌医学雑誌=The Sapporo Medical Journal en : The Sapporo Medical Journal 巻 88, 号 1-6, p. 21-35, 発行日 2019-12-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学 |