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抗生物質の相乗効果の機序についての実験的研究 : 特にAmpicillin（ABPc）とCloxacillin（MCIPc）の相乗作用について
https://doi.org/10.15114/smj.47.352
https://doi.org/10.15114/smj.47.352ad223639-212c-44d4-8d76-bee161749904
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
n0036472X474352.pdf (5.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2019-08-23 | |||||||||
| タイトル | ||||||||||
| タイトル | 抗生物質の相乗効果の機序についての実験的研究 : 特にAmpicillin（ABPc）とCloxacillin（MCIPc）の相乗作用について | |||||||||
| 言語 | ja | |||||||||
| タイトル | ||||||||||
| タイトル | Experimental Studies on the Mechanism of the Synergistic Effect of Combined Chemotherapy : Especially on the Synergistic Activity of Ampicillin and Cloxacillin | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.15114/smj.47.352 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
武内, 靖宏
× 武内, 靖宏
× 清水, 辰典
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| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 28772 | |||||||||
| 姓名 | Yasuhiro, Takeuchi | |||||||||
| 著者別名 | ||||||||||
| 識別子Scheme | WEKO | |||||||||
| 識別子 | 28773 | |||||||||
| 姓名 | Tatsunori, Shimizu | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Hitherto the majority of research on the synergistic activity of combined use of penicillins or penicillin and cephalosporin has been centered on in vitro studies rather than in vivo. In order to evaluate the efficacy of combined use of antibiotics, in vivo studies shoud be made. In this paper the synergistic activity of a one to one combination of ampicillin and cloxacillin was studied under varied experimental infection systems and at the same time some in vitro experiments were carried out. The results obtained are as follows. 1） In a systemic infection system in mice, the combined therapy showed an effective synergistic activity against E. coli infection. 2） In experimental urinary tract infection in rats, the combined use resulted in a marked decrease of viable cell counts in the kidneys. 3） In an infection system using rat granuloma pouch, combined use showed a stronger bactericidal activity in the exudate as compared with the results of single use of two penicillins alone. 4） Viable cells counts in the kidneys of mice infected with E. coli showed a marked decrease after treatment with combined therapy, however the single use of each penicillin showed little or no effect. 5） The inhibitory effect of cloxacillin on penicillinase was enhanced by the co-existence of normal rat tissue homogenate. 6） Inactivation of ampicillin by homogenates of mouse kidney infected with E. coli was inhibited by an addition of cloxacillin. 7） The activity of phagocytosis of macrophage was enhanced by the co-existence of ampicillin and cloxacillin as compared with the effect of the existence of each penicillin alone. 8） The uptake of penicillins by E. coli cells was enhanced by the co-existence of other penicillins. The results obtained above showed that the synergistic activity in vivo of the combination use of ampicillin and cloxacillin was effective, and it was suremised that the mechanism of synergistic effect of the combiced therapy was not simple. | |||||||||
| 書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 47, 号 4, p. 352-364, 発行日 1978-08-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0036-472X | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 出版者 | ||||||||||
| 出版者 | 札幌医科大学医学部 | |||||||||
