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レプトスピラの抗原変異と宿主の殺菌作用に対する感受性の変化
https://doi.org/10.15114/smj.60.323
https://doi.org/10.15114/smj.60.3234e60bbea-9f7f-4199-ad9d-6fb949d07ecd
名前 / ファイル | ライセンス | アクション |
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n0036472X604323.pdf (372.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
タイトル | Antigenic Modification of Leptospira and Change in Susceptibility to Host Bactericidal Effects | |||||
言語 | en | |||||
タイトル | ||||||
タイトル | レプトスピラの抗原変異と宿主の殺菌作用に対する感受性の変化 | |||||
言語 | ja | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Antigenic modification | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Host defense | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Leptospiral lipopolysaccharide | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Monoclonal antibody | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Variants | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/smj.60.323 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Isogai, Hiroshi
× Isogai, Hiroshi× Kawakami, Mitsuaki× Yoshida, Masaki× Oguma, Keiji× Miura, Hiroko× Isogai, Emiko |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25918 | |||||
姓名 | 磯貝, 浩 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25919 | |||||
姓名 | 川上, 光明 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25920 | |||||
姓名 | 吉田, 雅喜 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25921 | |||||
姓名 | 小熊, 恵二 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25922 | |||||
姓名 | 三浦, 宏子 | |||||
著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 25923 | |||||
姓名 | 磯貝, 恵美子 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Variant strains, induced by co-cultivation of Leptospira interrogans serovar copenhageni strain Shibaura with its homologous antiserum in a liquid medium, showed reduced agglutinability to the antiserum in comparison with that of the original parent Shibaura strain. The reduction was inversely correlated to the concentration of the antiserum in the medium. Furthermore, these variants showed reduced agglutinability to anti-leptospiral lipopolysaccharide (LPS) serum and antileptospiral LPS monoclonal antibodies. The variants became resistant to complement-mediated and macrophage-mediated bactericidal effects in the presence of antibody to the LPS. The level of resistance was related to the degree of the reduced agglutinability. The clearance time of these variants from the blood of the mice was observed to be longer than that of the parent Shibaura strain when these bacteria were inoculated into the mice immunized with heatinactivated parent Shibaura strain. It was concluded, therefore, that these variants acquired the ability to survive for a longer period in vivo than that of the parent organism. These results suggest that variation of Leptospires, which has been considered as a temporary modification of LPS, is one of the ways it escapes from the host defense mechanisms. | |||||
書誌情報 |
札幌医学雑誌 = The Sapporo medical journal en : The Sapporo medical journal 巻 60, 号 4, p. 323-329, 発行日 1991-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学医学部 |