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Establishment and Characterization of a Human Cell Line Derived from a Squamous Cell Carcinoma of the Tongue
https://doi.org/10.15114/tr.23.43
https://doi.org/10.15114/tr.23.43cc34e722-33e8-492c-b5a7-735cf3337e92
名前 / ファイル | ライセンス | アクション |
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n004140932343.pdf (5.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
タイトル | Establishment and Characterization of a Human Cell Line Derived from a Squamous Cell Carcinoma of the Tongue | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Squamous cell carcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cell line | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Epidermal growth factor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.23.43 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Yokoi, Toshikazu
× Yokoi, Toshikazu× Yamaguchi, Akira× Odajima, Tetsuyo× Furukawa, Kazunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A cell line designated as OSC-19 was established from the metastatic tumor which was found in a cervical lymph node of a male patient suffering squamous cell carcinoma (SCC) of tongue. OSC-19 cells were polygonal in shape and grew in a cobblestone pattern. Desmosomes and microvilli were observed by electron microscopic examination, but tonofilament bundles were scarce. However, immunofluorescence studies showed cytokeratins in the cytoplasms of OSC-19 cells. When inoculated into nude mice, OSC-19 cells had many distinctive desmosomes and plenty of tonofilament bundles. These observations suggested strongly that OSC-19 cell line was SCC in origin. OSC-19 cells had receptors of epidermal growth factor (EGF), but the growth of the cells in dish culture was inhibited by 1 to 100 ng/ml EGF in dose-dependent manners. OSC-19 cells could not grow in soft agar, suggesting that they were strongly anchorage dependent. However, in contrast to dish culture, EGF stimulated colony formation of OSC-19 cells in soft agar. These results suggested that EGF has complex effects on the cell growth. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 23, p. 43-57, 発行日 1988 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |
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Cite as
Yokoi, Toshikazu, Yamaguchi, Akira, Odajima, Tetsuyo, Furukawa, Kazunori, 1988, Establishment and Characterization of a Human Cell Line Derived from a Squamous Cell Carcinoma of the Tongue: Sapporo Medical University, 43–57 p.
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