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Review : The Discovery of the Widespread Microsatellite Instability Phenotype and Distinction of the Mutator and Suppressor Pathways for Gastrointestinal Cancer
https://doi.org/10.15114/tr.34.1
https://doi.org/10.15114/tr.34.1eaca1431-8791-4afb-b24c-57322102de0c
名前 / ファイル | ライセンス | アクション |
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n00414093341.pdf (585.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2019-07-31 | |||||
タイトル | ||||||
タイトル | Review : The Discovery of the Widespread Microsatellite Instability Phenotype and Distinction of the Mutator and Suppressor Pathways for Gastrointestinal Cancer | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Microsatellite instability | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DNA fingerprinting | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DNA repair | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Frameshift mutation | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15114/tr.34.1 | |||||
ID登録タイプ | JaLC | |||||
著者 |
Yamamoto, Hiroyuki
× Yamamoto, Hiroyuki× Itoh, Fumio× Iku, Shouhei× Fukushima, Hiroshi× Tang, Xiufen× Sasaki, Shigeru× Arimura, Yoshiaki× Motoya, Satoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This short review summarizes the molecular genetics of gastrointestinal cancer. The first part describes the serendipitous discovery of the widespread microsatellite instability (MSI) phenotype in 1993 during the analysis of gene-tic alterations in colorectal cancer progression by unbiased arbitrarily primed PCR (AP-PCR) DNA fingerprinting. The concept of ubiquitous mutations in simple repeated sequences is explained in this context. We also describe criteria for the distinction between true genomic instability versus sporadic alterations in microsatellite sequences due to the high background mutation rate of these unstable sequences, which become detectable in tumors because of their clonality. In the second part, we describe the molecular features that distinguish two pathways for gastrointestinal cancer, the suppressor and the mutator pathways. The model of the mutator that mutates other mutators is also discussed. As an illustrative example of the distinctive features in the genotype of tumors from the two pathways, the results of analysis of targeted mutations in the pro-apoptotic gene Box are described in some de-tail. | |||||
書誌情報 |
Tumor Research en : Tumor Research 巻 34, p. 1-13, 発行日 1999 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0041-4093 | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Sapporo Medical University |