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  1. 紀要
  2. 札幌医科大学医療人育成センター紀要
  3. 10号

Fruit fly as a model organism in the study of human diseases and drug discovery

https://doi.org/10.15114/jcme.10.21
https://doi.org/10.15114/jcme.10.21
f2bf1766-df38-47d3-b5bd-cc7e78b549ea
名前 / ファイル ライセンス アクション
l122371021.pdf l122371021.pdf (628.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-06-25
タイトル
タイトル Fruit fly as a model organism in the study of human diseases and drug discovery
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ID登録
ID登録 10.15114/jcme.10.21
ID登録タイプ JaLC
著者 Firzan, Nainu

× Firzan, Nainu

Firzan, Nainu

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Yoshinobu, Nakanishi

× Yoshinobu, Nakanishi

Yoshinobu, Nakanishi

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Akiko, Shiratsuchi

× Akiko, Shiratsuchi

Akiko, Shiratsuchi

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抄録
内容記述タイプ Abstract
内容記述 Drug discovery is a dynamic yet an ever-lasting topic in medicine that heavily relies on the application of modelorganisms. Through the use of suitable model organisms, pre-clinical testing of new drug candidates can be carried out tensively prior to further testing with humans. This has been proven, so far, as one of efficient ways to limit the emergence of new substances that are potentially harmful to individuals. Nevertheless, increasing public interest in the thical issues raised by the use of live model organisms, such as mice and rats, pushes urgent needs for alternative modelorganisms. To this end, fruit fly Drosophila melanogaster might be an appropriate model organism to be accounted r.With its long-standing history of use, Drosophila is an insect behind the revelation of striking similarity to humans as to basic biological mechanisms and their tight controls to maintain homeostasis. Impairment of such events in rosophila is linked to the emergence of metabolic-related diseases such as obesity and diabetes mellitus, the unsolved cases of neurodegenerative diseases, and the fall of host immune responses against various infectious agents. With a igh genetic similarity, about 75%, to humans, ease of maintenance, and the availability of various disease models constructed through genetic manipulation and/or chemical induction, Drosophila has been a very promising model organism in he field of drug discovery. With this in mind, it would be not surprising if this tiny yet powerful model organism will soon substitute our current in vivo platform in the pre-clinical testing of new drug candidates.
書誌情報 札幌医科大学医療人育成センター紀要 = Journal of center for medical education Sapporo Medical University
en : Journal of center for medical education Sapporo Medical University

巻 10, p. 21-32, 発行日 2019-03-31
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 札幌医科大学医療人育成センター
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