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Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells
https://sapmed.repo.nii.ac.jp/records/17538
https://sapmed.repo.nii.ac.jp/records/17538ca1aab92-294d-44ad-a60f-60aec34fd39d
名前 / ファイル | ライセンス | アクション |
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0036472X90170.pdf (1.5 MB)
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Item type | その他 / Others(1) | |||||
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公開日 | 2022-03-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
Kizuku, OHWADA
× Kizuku, OHWADA× Takumi, KONNO× Takayuki, KOHNO× Masaya, NAKANO× Tsuyoshi, OHKUNI× Ryo, MIYATA× Takuya, KAKUKI× Masuo, KONDOH× Kenichi, TAKANO× Takashi, KOJIMA |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 様々な組織の炎症性疾患と密接な関係があるHigh mobility group box-1(HMGB1)は,主に核内に局在して転写の制御を行うとともに,細胞死や炎症性の刺激によって細胞外に放出され細胞障害性のシグナルを誘導するとされている.アレルギー性鼻炎や慢性副鼻腔炎の病態においてHMGB1が密接な関連があり,今回われわれはHMGB1 がTGF-βシグナリングを介して3細胞間接着分子であるangulin-1/LSRの発現を低下させることでバリア機能を低下させることを明らかとした. | |||||
書誌情報 |
札幌医学雑誌=The Sapporo Medical Journal en : The Sapporo Medical Journal 巻 90, 号 1-6, p. 70-71, 発行日 2022-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0036-472X | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 札幌医科大学 |