{"created":"2023-05-15T09:09:21.400132+00:00","id":17538,"links":{},"metadata":{"_buckets":{"deposit":"134d411f-cb55-4abe-8df3-5c657a9bbf9c"},"_deposit":{"created_by":14,"id":"17538","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"17538"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00017538","sets":["1658:1659:2242"]},"author_link":["34938","34939","34940","34941","34942","34943","34944","34945","34946","34947"],"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-6","bibliographicPageEnd":"71","bibliographicPageStart":"70","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌=The Sapporo Medical Journal"},{"bibliographic_title":"The Sapporo Medical Journal","bibliographic_titleLang":"en"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"様々な組織の炎症性疾患と密接な関係があるHigh mobility group box-1（HMGB1）は，主に核内に局在して転写の制御を行うとともに，細胞死や炎症性の刺激によって細胞外に放出され細胞障害性のシグナルを誘導するとされている．アレルギー性鼻炎や慢性副鼻腔炎の病態においてHMGB1が密接な関連があり，今回われわれはHMGB1 がTGF-βシグナリングを介して3細胞間接着分子であるangulin-1/LSRの発現を低下させることでバリア機能を低下させることを明らかとした．","subitem_description_type":"Abstract"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kizuku, OHWADA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takumi, KONNO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takayuki, KOHNO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masaya, NAKANO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuyoshi, OHKUNI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ryo, MIYATA"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takuya, KAKUKI"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuo, KONDOH"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kenichi, TAKANO"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takashi, KOJIMA"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-18"}],"displaytype":"detail","filename":"0036472X90170.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0036472X90170.pdf","url":"https://sapmed.repo.nii.ac.jp/record/17538/files/0036472X90170.pdf"},"version_id":"20a8ca2e-fc5d-491a-8665-3ed4a5a04458"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"14","path":["2242"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-03-18"},"publish_date":"2022-03-18","publish_status":"0","recid":"17538","relation_version_is_last":true,"title":["Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-22T06:48:50.079444+00:00"}