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  1. 紀要
  2. Tumor Research
  3. Vol.28

Effect of Retinoic Acid on the Growth and the Expression of the Human Papillomavirus 16 E6 and E7 Genes of the Cervical Carcinoma Cell Lines

https://doi.org/10.15114/tr.28.63
https://doi.org/10.15114/tr.28.63
8617327f-dbf1-444b-ae02-2e4c732f3807
名前 / ファイル ライセンス アクション
n004140932863.pdf n004140932863.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2019-07-31
タイトル
タイトル Effect of Retinoic Acid on the Growth and the Expression of the Human Papillomavirus 16 E6 and E7 Genes of the Cervical Carcinoma Cell Lines
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Retinoic acid
キーワード
言語 en
主題Scheme Other
主題 Cervical carcinoma cell line
キーワード
言語 en
主題Scheme Other
主題 Growth suppression
キーワード
言語 en
主題Scheme Other
主題 Human papillomavirus type 16 (HPV16)
キーワード
言語 en
主題Scheme Other
主題 E6/E7 gene expression
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
ID登録
ID登録 10.15114/tr.28.63
ID登録タイプ JaLC
著者 Furuhata, Tomohisa

× Furuhata, Tomohisa

Furuhata, Tomohisa

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Yamashita, Toshiharu

× Yamashita, Toshiharu

Yamashita, Toshiharu

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Hirata, Koichi

× Hirata, Koichi

Hirata, Koichi

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Sugawara, Kenji

× Sugawara, Kenji

Sugawara, Kenji

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Fujinaga, Kei

× Fujinaga, Kei

Fujinaga, Kei

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抄録
内容記述タイプ Abstract
内容記述 Human papillomavirus type 16 (HPV16) is involved in the development of cervical carcinoma and its viral gene products E6 and E7 are believed to be essential for the carcinogenic process. We analyzed the effect of retinoic acid (RA) on the growth and/or HPV16 E6 and E7 gene expression in the HPV16-containing cervical carcinoma cell lines SiHa, CaSki and QG-U and the HPV-free cell lines C33A and EBC-1. RA (10-6 M) suppressed the growth of SiHa cells by more than 90% and of QG-U cells by about 40% ; however, the growth of CaSki, C33A and EBC-1 cells was not affected by RA. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was applied for investigation of the relationship between RA and the level of HPV16 E6/E7 mRNA. As a result, the E6/E7 mRNA level in SiHa and QG-U was reduced by RA by about 60% and 75%, respectively, while RA had no obvious effect on the E6 and E7 gene expression in CaSki cells. The chloramphenicol acetyltransfer-ase (CAT) assay showed that transcription driven by HPV16 non-coding region (NCR) was suppressed by RA by about 75%. These results suggest that at least a part of the growth suppression of SiHa and QG-U by RA is mediated by sup-pression of E6 and E7 expression.
書誌情報 Tumor Research
en : Tumor Research

巻 28, p. 63-76, 発行日 1993
ISSN
収録物識別子タイプ ISSN
収録物識別子 0041-4093
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版者
出版者 Sapporo Medical University
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Cite as

Furuhata, Tomohisa, Yamashita, Toshiharu, Hirata, Koichi, Sugawara, Kenji, Fujinaga, Kei, 1993, Effect of Retinoic Acid on the Growth and the Expression of the Human Papillomavirus 16 E6 and E7 Genes of the Cervical Carcinoma Cell Lines: Sapporo Medical University, 63–76 p.

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