Neuropathy in the patients with gastric cancer and primary hepatoma was quantitatively analyzed by the use of nerve conduction velocity of the peripheral nerves of the limbs, and the simultaneous serum folate level in fasting was determined by radioassay in order to investigate the etiological interrelationship. 1. Highly frequent subclinical neuropathy, motor dominant in gastric cancer, was proved by markedly delayed nerve conduction velocities in the patients with gastric cancer as well as primary hepatoma, and the literature survey turned out that this paper is the first systemic report of carcinomatous neuropathy in primary hepatoma. 2. The serum folate level was 2.4 ± 1.5 ng/m? in gastric cancer and 1.7 ± 1.0 ng/m? in primary hepatoma, and both were significantly low as compared with the normal value of 7.6 ± 2.4 ng/m? . 3. The coexistence with delayed nerve conduction velocity and low serum folate level was almost constant at a very high frequency in gastric cancer and primary hepatoma. 4. Therefore, it was assumed that low serum folate concentration could participate in the mechanism of developing so-called carcinomatous neuropathy.
癌病変に伴う末梢神経障害 : 特に血中葉酸濃度との関係について I. ヒト胃癌および肝癌についての臨床研究
n0036472X49165.pdf
(2.68MB)
