{"created":"2023-05-15T09:03:50.255559+00:00","id":8188,"links":{},"metadata":{"_buckets":{"deposit":"ec1d3b49-812a-45c4-b9c7-74c92a41972c"},"_deposit":{"created_by":15,"id":"8188","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"8188"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00008188","sets":["1674:1677:1680"]},"author_link":["6933","6934","6935","6936","6937"],"item_2_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A Trial to Improve the Screening for Congenital Adrenal Hyperplasia - Basic Study on the Enzaplate Neo-17α-OHP -"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"56","bibliographicPageStart":"48","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"札幌市衛生研究所年報 = Annual Report of Sapporo City Institute of Public Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CAHスクリーニング方法を改良する目的で，改良型抗体を用いる試薬であるエンザプレートNeo-17α-OHPについて，基礎的検討および従来型試薬であるN-17α-OHPや高感度HPLC法との比較等を行い，その有効性を検討した。その結果，低濃度から高濃度域までELISA法として十分な再現性があり（17-OHP直接法：CV=11.28-14.14％，17-OHP抽出法：CV=7.24-15.33%），従来法よりも真値に近く信頼性のある結果が得られ（新生児検体n=278のHPLC法対17-OHP抽出法相関：R=0.852，患者検体n=9の同相関：R=0.981），陽性者検出のためのカットオフ値の設定も可能なことから（17-OHP抽出法>4.5ng/ml），改良型試薬の導入が有効なスクリーニング法構築のための一つの選択肢となることが示された。","subitem_description_type":"Abstract"}]},"item_2_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌市衛生研究所"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-0294","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三上, 篤"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本間, かおり"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"水嶋, 好清"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"尾崎, 恒一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤田, 晃三"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-21"}],"displaytype":"detail","filename":"n091702942948.pdf","filesize":[{"value":"258.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n091702942948.pdf","url":"https://sapmed.repo.nii.ac.jp/record/8188/files/n091702942948.pdf"},"version_id":"54ee7da6-7587-45a6-92fb-628b12734b18"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"先天性副腎過形成症スクリーニング改良の試み : エンザプレートNeo-17α-OHPの基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"先天性副腎過形成症スクリーニング改良の試み : エンザプレートNeo-17α-OHPの基礎的検討","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"15","path":["1680"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-24"},"publish_date":"2009-03-24","publish_status":"0","recid":"8188","relation_version_is_last":true,"title":["先天性副腎過形成症スクリーニング改良の試み : エンザプレートNeo-17α-OHPの基礎的検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T04:40:46.814771+00:00"}