@article{oai:sapmed.repo.nii.ac.jp:00007997,
 author = {中川原, 譲二 and 松崎, 隆幸 and 和田, 啓二 and 武田, 利兵衛 and 戸島, 雅彦 and 川合, 裕 and 中村, 順一 and 末松, 克美},
 issue = {1},
 journal = {北海道脳神経疾患研究所医誌 = Journal of Hokkaido Brain Research Foundation},
 month = {Aug},
 note = {Eleven patients with symptomatic cerebral vasospasm following early surgery for ruptured aneurysm were examined postoperatively using single-photon emission computed tomography (SPECT) and N-isopropyl-123I-p-iodoamphetamine(IMP). IMP acquisitions were made 2 times after intravenous injection of 6mCi IMP. The early imaging was performed 10 minutes after injection, and the delayed imaging was obtained 5 hours after injection. In patients with reversible ischemia, moderate hypoactive areas due to vasospam were observed on the early image with incomplete redistribution on the delayed image, which were not detected by CT scan. Neurological recovery was accompanied by normalization of the early and delayed images. In patients with irreversible infarction, marked hypoactive or inactive areas due to vasospasm were revealed on the early image, without redistribution on the delayed image. Post-ischemic hyperactive areas were localized in the early or delayed images, which corresponded to the subacute infarcted area on the CT scan following the relaxation of cerebral vasospasm. Based on the above results of acute cerebral ischemia due to vasospasm, it is concluded that the early image indicates hemodynamic changes due to cerebral vasospasm, and the delayed image reveals a redistribution of IMP related to the functional reversibility of the acute ischemic brain tissue. In addition to that, it seemes important that chronology be taken into the consideration when regional brain perfusion and metabolic activity in patients with subacute infarcted area were evaluated by the early and delayed images of IMP SPECT.},
 pages = {8--16},
 title = {123Ｉ-IMP SPECTによる症候性脳血管攣縮例の脳循環動態の評価},
 volume = {1},
 year = {1988}
}