{"created":"2023-05-15T09:03:34.448792+00:00","id":7937,"links":{},"metadata":{"_buckets":{"deposit":"aa28360f-d735-4768-b48a-a3b45ef02403"},"_deposit":{"created_by":15,"id":"7937","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"7937"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00007937","sets":["1674:1675:1676"]},"author_link":["5587","5588"],"item_2_alternative_title_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Spa Water on Model Animal for Atopic Dermatitis"}]},"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-11-29","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"98","bibliographicPageStart":"96","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"北海道立衛生研究所報 = Report of the Hokkaido Institute of Public Health"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アトピー性皮膚炎(AD)は「増悪、寛解を繰り返す、掻痒のある湿疹を主病変とする疾患であり、患者の多くはアトピー素因を持つ」と定義される。その発症、増悪化には遺伝的要因と、環境汚染因子や社会的因子が深く関わっており、病態解析とこれに連動する根治療法の開発は遅れ、未だ十分な成功をおさめていない。近年、ADの発症メカニズムの解明や治療薬、治療法の開発において、自然発症ADモデル動物であるNC/Ngaマウスが注目を集めている。NC/Ngaマウスは通常の環境で飼育すると7?8週齢より出血、脱毛、頚部の痂皮の形成などの皮膚症状、痒みによる掻痒行動がみられ、耳介部の欠失がおこる。また、加齢とともにIgE値の上昇など、ADに類似した症状を示す。我々はこれまでに札幌在住の2名のAD患者に対し、豊富町より搬送された温泉水で1カ月間の温泉療法を行い、皮膚症状や倦怠感、ある種の免疫学的パラメータの改善など、良好な結果を得た。本論文では、道内温泉によるADの療養結果を評価するための予備的検討として、ADモデル動物であるNC/Ngaマウスに豊富町より搬送された温泉水を吹きかけ、皮膚症状、血清IgE値の変化を調べたので報告する。","subitem_description_type":"Abstract"}]},"item_2_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北海道立衛生研究所"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0441-0793","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"市橋, 大山"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内野, 栄治"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-21"}],"displaytype":"detail","filename":"n044107935296.pdf","filesize":[{"value":"891.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n044107935296.pdf","url":"https://sapmed.repo.nii.ac.jp/record/7937/files/n044107935296.pdf"},"version_id":"7ce37cc4-0bc9-4d09-a083-ce2599e358a2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アトピー性皮膚炎モデル動物を用いた温泉水の効能の評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アトピー性皮膚炎モデル動物を用いた温泉水の効能の評価","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"15","path":["1676"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-23"},"publish_date":"2009-03-23","publish_status":"0","recid":"7937","relation_version_is_last":true,"title":["アトピー性皮膚炎モデル動物を用いた温泉水の効能の評価"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T04:39:54.072803+00:00"}