{"created":"2023-05-15T09:03:24.373565+00:00","id":7718,"links":{},"metadata":{"_buckets":{"deposit":"e49296a3-01bf-4676-9398-2692f2e46762"},"_deposit":{"created_by":14,"id":"7718","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"7718"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00007718","sets":["1875:1885:1886"]},"author_link":["4662","4663","4664","4665","4666","4667","4668","4669","4670"],"control_number":"7718","item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"28","bibliographicPageStart":"24","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"市立室蘭総合病院医誌 = Journal of Muroran City General Hospital"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HBVキャリアは，通常小児期の無症候性キャリアを経て，青壮年期に慢性肝炎に移行する.その間に細胞性免疫によるHBV感染細胞の破壊を繰り返し，大多数は活動性の高い野生株が排除され，活動性の低い変異株が残り，ＨＢｅ抗原陰性，ＨＢｅ抗体陽性となり，GOT，GPTが持続正常化する無症候性キャリアとなる.しかしながら，今回我々はＨＢｓ抗原陽性，ＨＢｅ抗原陰性，ＨＢｅ抗体陽性の患者で重症肝障害を来たした3例を経験した.3例のうち2例が劇症肝炎亜急性型，1例が急性型に分類され，原因はHBVが1例，薬剤性が1例であり，残りの1例は特定できなかった.救命できなかった2症例はステロイドパルス療法後の感染症を契機に状態が悪化しており，感染症のコントロールが重要と考えられた.また，救命し得た1例は入院翌日にほぼ全ての内科的治療を開始しており，迅速な初期治療の開始が救命できた一因と考えられた","subitem_description_type":"Abstract"}]},"item_2_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"市立室蘭総合病院"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0289-2774","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大橋, 広和"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金戸, 宏行"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木, 秀一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大関, 令奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田沼, 徳真"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 修司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"下地, 英樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 晴夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安達, 雄哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"本田,佐保"}]},{"creatorNames":[{"creatorName":"一柳,伸吾"}]},{"creatorNames":[{"creatorName":"近藤,吉宏"}]},{"creatorNames":[{"creatorName":"赤保内,良和"}]},{"creatorNames":[{"creatorName":"小村,博昭"}]},{"creatorNames":[{"creatorName":"小西,康宏"}]},{"creatorNames":[{"creatorName":"今,信一郎"}]},{"creatorNames":[{"creatorName":"阿部,直之"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-21"}],"displaytype":"detail","filename":"n0289277428124.pdf","filesize":[{"value":"667.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0289277428124.pdf","url":"https://sapmed.repo.nii.ac.jp/record/7718/files/n0289277428124.pdf"},"version_id":""}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HBVキャリア","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"劇症肝炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"内科的治療","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"当科にて経験したHBs抗原陽性の重症肝障害の3例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"当科にて経験したHBs抗原陽性の重症肝障害の3例","subitem_title_language":"ja"}]},"item_type_id":"2","owner":"14","path":["1886"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-03-18"},"publish_date":"2009-03-18","publish_status":"0","recid":"7718","relation_version_is_last":true,"title":["当科にて経験したHBs抗原陽性の重症肝障害の3例"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T03:13:54.515551+00:00"}