@article{oai:sapmed.repo.nii.ac.jp:00016509, author = {伊藤, 格 and 日景, 史人 and 井田, 洋輔 and 大黒, 浩}, issue = {1-6}, journal = {札幌医学雑誌=The Sapporo Medical Journal, The Sapporo Medical Journal}, month = {Dec}, note = {PURPOSE: To elucidate the molecular pathology of deepening of the upper eyelid sulcus (DUES) induced by prostaglandin analogues (PGs), through a three-dimension (3D) tissue culture system using human orbital fibroblasts (HOFs)., METHODS: Effects of either 100 nM bimatoprost acid (BIM) or 100 nM prostaglandin F2α (PGF2α) were examined for the 3D organoids from HOFs. The size of BIM and PGF2α organoids were measured during cultivation, and evaluated the expression of the extracellular matrix (ECM) by immunolabeling and quantitative PCR.}, pages = {37--44}, title = {3次元培養法による上眼瞼溝深化(deepening of the upper eyelid sulcus : DUES)の分子病態に関する検討}, volume = {88}, year = {2019} }