{"created":"2023-05-15T09:08:40.873945+00:00","id":16342,"links":{},"metadata":{"_buckets":{"deposit":"3e7cbdea-aa13-46c7-affa-87becbce720a"},"_deposit":{"created_by":14,"id":"16342","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"16342"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00016342","sets":["1875:1879:2168"]},"author_link":["32103","32104","32105","32106","32107","32108","32109","32110"],"item_2_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-10-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"6","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"函館医学誌 = Hakodate medical journal"},{"bibliographic_title":"Hakodate medical journal","bibliographic_titleLang":"en"}]}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BRAF V600E 遺伝子変異は本邦では大腸癌の4.5-6.7％の頻度と報告されている１）。KRAS/NRAS 遺伝子変異とは相互排他的であり，BRAF V600E 遺伝子変異は予後不良因子とされる。欧州臨床腫瘍学会のガイドラインではBRAF V600E 遺伝子変異を有する切除不能進行再発大腸癌患者に対する全身化学療法の一次治療レジメンとして，FOLFOXIRI（fluorouracil＋leucovorin＋oxaliplatin＋irinotecan）＋Bevacizumab 療法が第一選択とされているが２），本邦では2018年３月の段階でBRAFV600E 遺伝子変異検査は大腸癌において保険償還されていないため，変異の有無確認は一般診療では困難であり，適切な治療が行われているとは言えない状況にある。","subitem_description_type":"Abstract"}]},"item_2_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"市立函館病院"}]},"item_2_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0910-0725","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"畑中, 一映"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北潟谷, 隆"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"霜田, 佳彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 淳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野, 正芳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"工藤, 大樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 義也"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"成瀬, 宏仁"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-09"}],"displaytype":"detail","filename":"n091007254216.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"n091007254216","url":"https://sapmed.repo.nii.ac.jp/record/16342/files/n091007254216.pdf"},"version_id":"126da2f3-cd7f-4f72-911e-b5365327a0a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colon cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"BRAF mutation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"当院におけるBRAF V600E 遺伝子変異を有する 切除不能進行再発大腸癌の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"当院におけるBRAF V600E 遺伝子変異を有する 切除不能進行再発大腸癌の検討","subitem_title_language":"ja"},{"subitem_title":"A retrospective study for patients with BRAF V600E mutant unresectable and metastatic colorectal cancer in Hakodate Municipal Hospital","subitem_title_language":"en"}]},"item_type_id":"2","owner":"14","path":["2168"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-09"},"publish_date":"2019-10-09","publish_status":"0","recid":"16342","relation_version_is_last":true,"title":["当院におけるBRAF V600E 遺伝子変異を有する 切除不能進行再発大腸癌の検討"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T03:02:39.356321+00:00"}