{"created":"2023-05-15T09:08:40.096108+00:00","id":16321,"links":{},"metadata":{"_buckets":{"deposit":"7b091506-81cc-4920-93e8-d76666bf0c1e"},"_deposit":{"created_by":15,"id":"16321","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"16321"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00016321","sets":["1658:1766:1855"]},"author_link":["32041","32042","32043","32044","32037","32038","32039","32040"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"13","bibliographicPageStart":"9","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"札幌医科大学保健医療学部紀要 = Bulletin of School of Health Sciences Sapporo Medical University"},{"bibliographic_title":"Bulletin of School of Health Sciences Sapporo Medical University","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"各種の悪性腫瘍で増加する糖鎖であるsialyl Lewis X（SLEX）が正常リンパ組織、末梢血や皮膚においてどのような発現をしているのかを免疫組織化学やフローサイトメトリーにて検索した。SLEXは末梢血のリンパ球において、NK細胞やT細胞の一部に発現していた。リンパ節では傍皮質やリンパ洞の一部の組織球に発現しており、特に皮膚病性リンパ節炎ではS100陽性の樹状細胞（Langerhans細胞）の一部にSLEXが陽性であった。また、皮膚表皮でもCD1a陽性Langerhans細胞の一部がSLEX陽性であった。以上の所見から、従来指摘されていた表皮の抗原提示細胞であるLangerhans細胞のリンパ節への移行が確認された。更にこのLangerhans細胞移行の機序には内皮細胞E-selectinとLangerhans細胞SLEXの相互反応が関与する可能性が示唆された。Tissue distribution of sialyl Lewis X（SLEX） in the lymphoid tissues and peripheral blood lymphocytes was studied by immunohistochemistry and flow cytometry. SLEX was expressed in the subpopulation of T cells and natural killer cells of peripheral blood and histiocytes of paracortical areas of lymph nodes. In the dermatopathic lymphadenopathy, some S100+dendritic cells of the paracortical area were positive for SLEX. A subpopulation of CD1a-positiveepidermal dendritic cells expressed SLEX. These results showed that SLEX was ex-pressed in a subpopulation of Langerhans cells, which are antigen-presenting cells to T-cells. The migration of Langerhans cells from skin to lymph nodes is thought to be performed via the interaction of SLEX of Langerhans cells and E-selectin of the endothelial cells.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"32041","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kiyoshi, KASAI"}]},{"nameIdentifiers":[{"nameIdentifier":"32042","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shinichiro, KON"}]},{"nameIdentifiers":[{"nameIdentifier":"32043","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akihiro, MATSUURA"}]},{"nameIdentifiers":[{"nameIdentifier":"32044","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kokichi, KIKUCHI"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/bshs.1.9","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学保健医療学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9192","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"笠井, 潔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今, 信一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松浦, 晃洋"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菊地, 浩吉"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-11"}],"displaytype":"detail","filename":"n1344919219.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n1344919219.pdf","url":"https://sapmed.repo.nii.ac.jp/record/16321/files/n1344919219.pdf"},"version_id":"8653090e-2ab7-4568-997e-606f35c13765"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sialyl Lewis X","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ランゲルハンス細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"樹状細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"CD1抗原","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Sialyl Lewis X","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Langerhans cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendritic cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD1 antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"樹状細胞におけるSialyl Lewis X 発現の免疫組織化学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"樹状細胞におけるSialyl Lewis X 発現の免疫組織化学的検討","subitem_title_language":"ja"},{"subitem_title":"Immunohistochemical Localization of Sialyl Lewis X Expression in Dendritic Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1855"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-09-11"},"publish_date":"2019-09-11","publish_status":"0","recid":"16321","relation_version_is_last":true,"title":["樹状細胞におけるSialyl Lewis X 発現の免疫組織化学的検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:56:52.520528+00:00"}