{"created":"2023-05-15T09:08:39.900138+00:00","id":16318,"links":{},"metadata":{"_buckets":{"deposit":"9d5129ba-5f7a-4fe2-bf3b-e51520906539"},"_deposit":{"created_by":15,"id":"16318","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"16318"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00016318","sets":["1658:1766:1855"]},"author_link":["32017","32018","32015","32016"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"36","bibliographicPageStart":"31","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"札幌医科大学保健医療学部紀要 = Bulletin of School of Health Sciences Sapporo Medical University"},{"bibliographic_title":"Bulletin of School of Health Sciences Sapporo Medical University","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カエル縫工筋標本の収縮に対するプロスタグランヂン（PGs）の作用およびその作用機序について検討した。100μMのPGE２とPGF２αは、筋の静止張力に影響を与えなかったが、１μM以上では、単収縮張力を増大させた。PGsの単収縮増大作用は、カフェイン存在下でさらに強化された。10μMのPGE２は、収縮潜時に影響を与えることなく、単収縮張力と50％弛緩時間を著しく増大、遅延させた。カフェイン拘縮もまた、10μMのPGE２を添加したＫ脱分極筋や400μMグリセリン高張リンゲル液に60分間処理した筋で強化された。以上の結果から、PGsは興奮収縮連関に作用するのではなく、弛緩過程に作用するものと考えられる。カエル縫工筋標本におけるPGsの収縮強化効果は、筋小胞体へのCa２+の取り込み過程の抑制による可能性が示唆された。The effects of prostaglandins（PGs）on contractile responses of the frog sartorius muscle were studied. PGE２ and PGF２α at a concentration of 100μM did not affect static muscle tone, but these PGs at concentrations higher than 1μM enhanced twitch tension. The increasing effects of PGs on twitch tension were enhanced in the presence of caffeine. PGE２ at a concentration of 10μM markedly increased tension of the twitch and 50% relaxation time, without having any effect on latency. Caffeine contracture was also enhanced by PGE２（10μM）in the K-depolarized muscle and in the muscle treated with 400mM glycerol in addition to Ringer solution for 60 min. From these results and reports, it is surmised that PGs may act on relaxation process, not on the excitation-contraction process, and that the enhancement effect of PGs on contractile responses of frog sartorius muscle may depend on an inhibition of Ca２＋ re-up take into the sarcoplasmic reticulum in the muscle cell.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"32017","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimiharu, INUI"}]},{"nameIdentifiers":[{"nameIdentifier":"32018","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mitsuo, ISHIZAWA"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/bshs.1.31","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学保健医療学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9192","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"乾, 公美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石澤, 光郎"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-11"}],"displaytype":"detail","filename":"n13449192131.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n13449192131.pdf","url":"https://sapmed.repo.nii.ac.jp/record/16318/files/n13449192131.pdf"},"version_id":"d0aa8ca3-4891-4eab-8d77-50578b16f4e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カエル縫工筋","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"単収縮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"プロスタグランヂンE２","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"?F２α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"カフェイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Frog sartorius muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Twitch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostaglandin E２","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"?F２α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Caffeine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カエル縫工筋に対するプロスタグランヂンの収縮増強作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カエル縫工筋に対するプロスタグランヂンの収縮増強作用","subitem_title_language":"ja"},{"subitem_title":"Enhancement Effect of Prostaglandins on the Contractile Responses of the Frog Sartorius Muscle","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1855"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-09-11"},"publish_date":"2019-09-11","publish_status":"0","recid":"16318","relation_version_is_last":true,"title":["カエル縫工筋に対するプロスタグランヂンの収縮増強作用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:56:51.963885+00:00"}