{"created":"2023-05-15T09:08:38.524139+00:00","id":16291,"links":{},"metadata":{"_buckets":{"deposit":"d8dc8783-6d54-431b-ae4e-9b6540e715bd"},"_deposit":{"created_by":15,"id":"16291","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"16291"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00016291","sets":["1658:1766:1853"]},"author_link":["31860","31861","31862","31857","31858","31859"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"89","bibliographicPageStart":"83","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"札幌医科大学保健医療学部紀要 = Bulletin of School of Health Sciences Sapporo Medical University"},{"bibliographic_title":"Bulletin of School of Health Sciences Sapporo Medical University","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"後肢懸垂による廃用性筋萎縮モデルラットを用い、(1)後肢懸垂に伴う神経筋伝達機能の変化と、(2)懸垂萎縮筋に対する筋伸張の影響を調べることを目的とした。後肢懸垂群（HS群）、後肢懸垂+筋伸張群（HS+MS群）、対照群（CONT群）の３群に対し、２週間の後肢懸垂後、ヒラメ筋-脛骨神経標本の微小終板電位（m.e.p.p.）を測定した。その結果、HS群とHS+MS群のm.e.p.p.立ち上がり時間は、CONT群に比べて有意に延長した（P<0.05）。また、HS群とHS+MS群のm.e.p.p.発生頻度は、CONT群に比べて有意に低下した（P<0.05）が、HS群とHS+MS群に有意差はなかった。後肢懸垂に伴うm.e.p.p.の変化については、シナプス間隙、acetylcholinesterase活性、神経終板領域との関連から考察した。懸垂萎縮筋に対して筋伸張の影響が見られなかった原因として、(1)筋萎縮防止の程度が不十分だった、(2)筋伸張はm.e.p.p.の維持に関与しない、の二点が可能性として考えられた。The purpose of this study was to investigate in rats whether neurotransmitter release was altered with hindlimb suspension, and to see how the muscle stretching affected disuse atrophy when precipitated by hindlimb suspension. The rats were divided into 3 groups: hindlimb suspension （HS）,hindlimb suspension+muscle stretching （HS+MS）and control（CONT）Miniature end plate potential （m.e.p.p.）was measured after 2 weeks of hindlimb suspension. M.e.p.p. rise time was significantly more prolonged in HS and HS+MS than in CONT （P<0.05）. The frequency of m.e.p.p.was significantly greater in HS and HS+MS than in CONT （P<0.05）, but was not significantly different between HS and HS+MS. The alterations of m.e.p.p. with hindlimb suspension were discussed from the point of view of synaptic gap junctions, activity of acetylcolinesterase, and end plate area. The reason why muscle stretching could not have affected m.e.p.p. was considered to be that muscle disuse atrophy was insufficiently prevented and that muscle stretching did not correlate with sustaining m.e.p.p..","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"31860","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hidehiko, KOMINE"}]},{"nameIdentifiers":[{"nameIdentifier":"31861","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimiharu, INUI"}]},{"nameIdentifiers":[{"nameIdentifier":"31862","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mistuo, ISHIZAWA"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/bshs.3.83","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学保健医療学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9192","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小峰, 秀彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"乾, 公美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石澤, 光郎"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-11"}],"displaytype":"detail","filename":"n13449192383.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n13449192383.pdf","url":"https://sapmed.repo.nii.ac.jp/record/16291/files/n13449192383.pdf"},"version_id":"234cf330-a4dc-44c6-b018-0c8e6561d21f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"後肢懸垂","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"廃用性筋萎縮","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"微小終板電位（m.e.p.p.）","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"筋伸張","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"Hindlimb suspension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Disuse muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"m.e.p.p.","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle stretching","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラット懸垂萎縮筋と懸垂中に伸張を与えたヒラメ筋の微小終板電位（m.e.p.p.）について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット懸垂萎縮筋と懸垂中に伸張を与えたヒラメ筋の微小終板電位（m.e.p.p.）について","subitem_title_language":"ja"},{"subitem_title":"Miniture end plate potential in atrophied muscle with hindlimb suspension and in muscle stretched during hindlimb suspension in rats","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1853"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-09-11"},"publish_date":"2019-09-11","publish_status":"0","recid":"16291","relation_version_is_last":true,"title":["ラット懸垂萎縮筋と懸垂中に伸張を与えたヒラメ筋の微小終板電位（m.e.p.p.）について"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:55:56.724957+00:00"}