{"created":"2023-05-15T09:08:33.804515+00:00","id":16182,"links":{},"metadata":{"_buckets":{"deposit":"80a2f46a-ac34-4b82-bfde-e508dc658345"},"_deposit":{"created_by":15,"id":"16182","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"16182"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00016182","sets":["1658:1766:1847"]},"author_link":["30797","30798","30799","30800","30793","30794","30795","30796"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"21","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"札幌医科大学保健医療学部紀要 = Bulletin of School of Health Sciences Sapporo Medical University"},{"bibliographic_title":"Bulletin of School of Health Sciences Sapporo Medical University","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"眼球運動失行を伴う失調症（AOA1）はaprataxin遺伝子の変異により起こる疾患である。本研究では、アデノウイルスを用いて野生型 aprataxin cDNA、689insT変異型aprataxin cDNA、LacZを発現するcDNAのそれぞれを培養ラット末梢髄鞘に導入したもの（Wild, Mt, LacZ）と導入しない培養ラット末梢髄鞘（NC）を作製・培養し、絞輪間距離の計測を行った。遺伝子導入後、Wild、Mt、LacZ、NCの4群間における絞輪間距離の比較ではNCとWildの間（P<0.O1）、LacZとWildの間（P<0.001）に有意差を認め、Mtは他の3群と有意差を認めなかった。この結果から、末梢神経細胞に対してMtの機能は優性阻害の影響はなく機能の喪失であり、Wildで起こるaprataxinの過剰な発現は、Schwann細胞の配列後に起こる伸長や、髄鞘化の開始、軸索の伸長に何らかの影響を及ぼす可能性が推測された。","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"30797","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshitaka, Horimoto"}]},{"nameIdentifiers":[{"nameIdentifier":"30798","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shin, KIKUCHI"}]},{"nameIdentifiers":[{"nameIdentifier":"30799","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nobutada, TACHI"}]},{"nameIdentifiers":[{"nameIdentifier":"30800","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Naoki, KOZUKA"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/bshs.13.21","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学保健医療学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9192","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀本, 佳誉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"菊池, 真"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"舘, 延忠"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小塚, 直樹"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-11"}],"displaytype":"detail","filename":"n134491921321.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n134491921321.pdf","url":"https://sapmed.repo.nii.ac.jp/record/16182/files/n134491921321.pdf"},"version_id":"5df09c2e-5fe4-4231-be56-5fd193a942fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アプラタキシン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"末梢神経","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"培養神経","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"絞輪間距離","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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