{"created":"2023-05-15T09:07:52.852591+00:00","id":15304,"links":{},"metadata":{"_buckets":{"deposit":"42cff201-12fe-4bed-9b6a-15a0c2091ec8"},"_deposit":{"created_by":15,"id":"15304","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15304"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00015304","sets":["1658:1659:1752"]},"author_link":["28247","28248","28245","28246"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1979-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"428","bibliographicPageStart":"415","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Studies on the mechanism of duodenal ulceration in rats induced by administration of cysteamine were carried out. The results obtained were as follows ; （1） Remarkable and significant secretions of gastric acid and pepsin were observed with marked distention of the stomach. However, pepsinogen content in the fundic mucosa was significantly decreased. （2） Cysteamine administration, which gave rise to edema in 5 minutes in the upper portion of villi of the duodenal mucosa with gradual mucosal damage with lapse of time, resulted in the extremely high incidence of duodenal ulceration at 12 hours. （3） Influence of cysteamine upon the various organs was histologically negligible except for the adrenal glands which showed severe hemorrhage. （4） Pancreatic exocrine secretions increased by administration of cysteamine alone, whereas they were decreased by the pancreozymin-secretin test. （5） Gastrin, glucagon, insulin, glucose and corticosterone levels in blood were significantly increased after administration of cysteamine, whereas plasma secretin levels were significantly decreased. On the other hand, release of secretin in rats pre-treated by cysteamine was decreased by intraduodenal administration of hydrochloric acid.  In conclusion, it was suggested that edema selectively induced in the duodenum and the remarkable secretions of gastric acid and pepsin were mainly involved in the induction of duodenal ulceration by cysteamine. It was also presumed that the dramatic changes of the several humoral factors and associated hemorrhage of the adrenal glands played synergetic roles in the development of duodenal ulceration.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"28247","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshikazu, Narasaki"}]},{"nameIdentifiers":[{"nameIdentifier":"28248","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuyoshi, Yabana"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.48.415","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楢崎, 義一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢花, 剛"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-23"}],"displaytype":"detail","filename":"n0036472X484415.pdf","filesize":[{"value":"6.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X484415.pdf","url":"https://sapmed.repo.nii.ac.jp/record/15304/files/n0036472X484415.pdf"},"version_id":"d81c795e-607d-4bf4-9c01-3bce9be40738"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"消化性潰瘍に関する実験的研究 : ラットにおけるシステアミン十二指腸潰瘍の発症機序について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"消化性潰瘍に関する実験的研究 : ラットにおけるシステアミン十二指腸潰瘍の発症機序について","subitem_title_language":"ja"},{"subitem_title":"Experimental Studies on Peptic Ulcer : On the Mechanism of Duodenal Ulcer Formation after Administration of Cysteamine in Rat","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1752"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-23"},"publish_date":"2019-08-23","publish_status":"0","recid":"15304","relation_version_is_last":true,"title":["消化性潰瘍に関する実験的研究 : ラットにおけるシステアミン十二指腸潰瘍の発症機序について"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:31:30.282453+00:00"}