{"created":"2023-05-15T09:07:51.291379+00:00","id":15280,"links":{},"metadata":{"_buckets":{"deposit":"e81ceb6b-4ec9-4294-9d6b-6399711dfc99"},"_deposit":{"created_by":15,"id":"15280","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"15280"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00015280","sets":["1658:1659:1752"]},"author_link":["28136","28137","28138","28133","28134","28135"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1979-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"166","bibliographicPageStart":"157","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An investigation was conducted on 104 gastric cancer patients with the focus of attention on the systemic and local lymph node immune responses against 3M  KCl extracts of tumor cells and the following results were obtained. 1） KC1 antigens were extracted from tumor cells of gastric cancer tissues and cells in ascites and LMI tests were conducted. In the autologous reactions, positive results were recognized in 4 cases out of 19 （21.1%）. Even in patients with advanced gastric cancer, it was shown that immune response against autologous tumor cells was present. 2） In a similar manner, positive results were observed in 1 out of 7 cases for lymphocyte transformation test and in 3 out of 15 cases for skin test, respectively. 3） The relationship between immune response against KC1 antigen and therapy was investigated and in the patient group receiving irnmunochemotherapy an increasing trend was seen in the incidence of positive LMI test. 4） The KCl extracts were separated through gel filtration. The 2nd and 3rd fractions obtained revealed an increased activity in the reaction of LMI test and lymphocyte transformation test as compared with crude KCl extracts. No special relation was seen between the CEA concentration in the KC） antigen and LMI tests. 5） It was found that generally the local cell-mediated immune response using lymphocytes of regional lymph nodes was more remarkable as compared with systemic cell-mediated immune response. Further, it was clarified that there was a good correlation between the local lymph node cell-mediated immune response against KC1 antigens and the development of gastric cancer.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"28136","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yukio, Hosokawa"}]},{"nameIdentifiers":[{"nameIdentifier":"28137","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kohzoh, Imai"}]},{"nameIdentifiers":[{"nameIdentifier":"28138","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akira, Yachi"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.48.157","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細川, 幸夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 浩三"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷内, 昭"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-23"}],"displaytype":"detail","filename":"n0036472X482157.pdf","filesize":[{"value":"4.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X482157.pdf","url":"https://sapmed.repo.nii.ac.jp/record/15280/files/n0036472X482157.pdf"},"version_id":"2b9f03b8-1426-4bbc-9193-d21d496deae1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胃癌患者の系統的ならびに局所リンパ節の細胞性免疫応答に関する研究 : 3M KCl 抽出抗原を中心に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌患者の系統的ならびに局所リンパ節の細胞性免疫応答に関する研究 : 3M KCl 抽出抗原を中心に","subitem_title_language":"ja"},{"subitem_title":"Studies on Systemic and Local Lymph Node Immune Responses in Patients with Gastric Cancer : With Special Reference to 3M KCl Extracts of Tumor Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1752"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-23"},"publish_date":"2019-08-23","publish_status":"0","recid":"15280","relation_version_is_last":true,"title":["胃癌患者の系統的ならびに局所リンパ節の細胞性免疫応答に関する研究 : 3M KCl 抽出抗原を中心に"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-12-13T02:31:26.162117+00:00"}