{"created":"2023-05-15T09:07:34.959050+00:00","id":14994,"links":{},"metadata":{"_buckets":{"deposit":"a982c2de-0b8f-46b8-b28d-0f14ba220415"},"_deposit":{"created_by":14,"id":"14994","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14994"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014994","sets":["1658:1659:1719"]},"author_link":["27034","27035","27036","27037","27038","27039","27028","27029","27030","27031","27032","27033"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"611","bibliographicPageStart":"603","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A new cell line of a human uterine cervical adenocarcinoma, designated as CAC-1, was established from a moderately differentiated adenocarcinoma of the uterine cervix. CAC-1 was subcultivated more than 150 times during 36 month period. The population doubling time was 31 hours. The number of chromosomes in the majority of cells was hypertriploidy with a mode of 75 at passage 51. In the cytoplasm, alcian blue, PAS and CEA staining positive substances could be seen. The cells produced CA-125, hCG and TPA in cultured media. The tumor obtained from nude mice inoculated with CAC-1 cells was a moderately differentiated adenocarcinoma histologically, closely resembling the original human tumor. CAC-1 was studied for chemosensitivity against 12 anticancer drugs by in vitro colony forming assay. In vitro sensitivity was defined as a 70% or greater inhibition of colony formation when compared to controls. Etoposide, mitomycin C and cisplatin showed sensitivity at peak plasma concentrations for 1 hour exposure. The 8 drugs, which showed sensitivity at 1/10 peak plasma concentration for 24 hour exposure, were aclacinomycin, actinomycin D, mitomycin C, etoposide, adriamycin, vincristine, vinblastine and cisplatin.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"27034","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hayakawa, Osamu"}]},{"nameIdentifiers":[{"nameIdentifier":"27035","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kudo, Ryuichi"}]},{"nameIdentifiers":[{"nameIdentifier":"27036","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamamoto, Hiroyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"27037","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kotsumi, Motoiki"}]},{"nameIdentifiers":[{"nameIdentifier":"27038","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamaucie, Osamu"}]},{"nameIdentifiers":[{"nameIdentifier":"27039","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takehara, Masaki"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.57.603","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"早川, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山内, 修"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"工藤, 隆一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山本, 裕之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小泉, 基生"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹原, 正輝"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X576603.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X576603.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14994/files/n0036472X576603.pdf"},"version_id":"02b97375-48e8-4cf8-9f32-bfe68a47960f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Established cell line","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Uterine cervical adenocarcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CA-125","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemosensitivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"In vitro colony forming assay","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討","subitem_title_language":"ja"},{"subitem_title":"Establishment and Characterization of a Cell Line Derived from Human Uterine Cervical Adenocarcinoma and Its Chemosensitivity to Anticancer Drugs","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1719"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14994","relation_version_is_last":true,"title":["ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:34.965611+00:00"}