@article{oai:sapmed.repo.nii.ac.jp:00014994,
 author = {早川, 修 and 山内, 修 and 工藤, 隆一 and 山本, 裕之 and 小泉, 基生 and 竹原, 正輝},
 issue = {6},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Dec},
 note = {A new cell line of a human uterine cervical adenocarcinoma, designated as CAC-1, was established from a moderately differentiated adenocarcinoma of the uterine cervix. CAC-1 was subcultivated more than 150 times during 36 month period. The population doubling time was 31 hours. The number of chromosomes in the majority of cells was hypertriploidy with a mode of 75 at passage 51. In the cytoplasm, alcian blue, PAS and CEA staining positive substances could be seen. The cells produced CA-125, hCG and TPA in cultured media. The tumor obtained from nude mice inoculated with CAC-1 cells was a moderately differentiated adenocarcinoma histologically, closely resembling the original human tumor. CAC-1 was studied for chemosensitivity against 12 anticancer drugs by in vitro colony forming assay. In vitro sensitivity was defined as a 70% or greater inhibition of colony formation when compared to controls. Etoposide, mitomycin C and cisplatin showed sensitivity at peak plasma concentrations for 1 hour exposure. The 8 drugs, which showed sensitivity at 1/10 peak plasma concentration for 24 hour exposure, were aclacinomycin, actinomycin D, mitomycin C, etoposide, adriamycin, vincristine, vinblastine and cisplatin.},
 pages = {603--611},
 title = {ヒト子宮頸部腺癌培養細胞株(CAC-1)の樹立とその性状および各種抗癌剤に対する感受性の検討},
 volume = {57},
 year = {1988}
}