{"created":"2023-05-15T09:07:34.767269+00:00","id":14991,"links":{},"metadata":{"_buckets":{"deposit":"10d35d6f-d666-471f-8306-d42fe4b50b1d"},"_deposit":{"created_by":14,"id":"14991","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14991"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014991","sets":["1658:1659:1719"]},"author_link":["27021","27022","27023","27018","27019","27020"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"580","bibliographicPageStart":"571","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Localization of bone γ-carboxyglutamic acid-containing protein （BGP）, also called osteocalcin, was investigated immumocytochemically by light and electron microscopy in human bones in various developmental stages using antihuman BGP antibodies. In the bones of 12 weeks fetus, osteoblasts strongly stained in the areas of endochondral and intramembranous bone formation. In the bones of late fetal stages, newborn, and adult, BGP was predominantly localized in the osteoid and bone matrix in the ossifying front. Osteoblasts and osteocytes also stained positive, but less dominantly than those in the early fetus. By electron-microscopy, BGP was localized in the cisternae of ER and the Golgi apparatus of osteoblasts and osteocytes, and collagen fibers of the osteoid and bone matrix. These observations indicate that BGP is synthesized by osteoblasts most actively in the early fetal life and then deposited to collagen fibers of osteoid and bone matrix.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"27021","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohta, Takayuki"}]},{"nameIdentifiers":[{"nameIdentifier":"27022","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuyama, Toshikatsu"}]},{"nameIdentifiers":[{"nameIdentifier":"27023","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ogawa, Katsuhiro"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.57.571","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"太田, 貴之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松山, 敏勝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 勝洋"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X576571.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X576571.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14991/files/n0036472X576571.pdf"},"version_id":"d405292c-15a2-452f-b338-6567f8b97c97"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bone gla protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteocalcin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunocytochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteogenesis.","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"成長期のヒト骨組織内におけるγ-carboxyglutamicacid含有蛋白の局在に関する研究 : 蛋白質の精製,抗体の精製,及び免疫組織学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成長期のヒト骨組織内におけるγ-carboxyglutamicacid含有蛋白の局在に関する研究 : 蛋白質の精製,抗体の精製,及び免疫組織学的研究","subitem_title_language":"ja"},{"subitem_title":"Immunocytochemical Localization of Bone y-carboxyglutamic Acid Containing Protein in the Developing Human Bone : Purification of the Protein, Preparation of the Antibody, and Immunocytochemical Analysis","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1719"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14991","relation_version_is_last":true,"title":["成長期のヒト骨組織内におけるγ-carboxyglutamicacid含有蛋白の局在に関する研究 : 蛋白質の精製,抗体の精製,及び免疫組織学的研究"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:34.421333+00:00"}