{"created":"2023-05-15T09:07:34.318661+00:00","id":14984,"links":{},"metadata":{"_buckets":{"deposit":"e3681ea9-ec3b-4e7c-9f45-1aac1198a091"},"_deposit":{"created_by":14,"id":"14984","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14984"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014984","sets":["1658:1659:1719"]},"author_link":["26997","26998","26999","26994","26995","26996"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"494","bibliographicPageStart":"485","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A new experimental model was developed in rats to investigate the local immune mechanism in the hepatobiliary tract. Animals were initially sensitized with subcutaneous injection of horseradish peroxidase（HRP） in the hind foot pads followed by retrograde boosting with the same antigen through the common bile duct 8 weeks after the initial sensitization（ID-rat）. Rats which were boosted intravenously with HRP （IV-rat）, which recieved HRP into the common bile duct without initial sensitization（S-rat）, and normal rats served as control. The number of anti-HRP antibody forming cells increasd significantly in the portal triad of the liver in the ID-rats. These cells were shown to be positive for lgA by double immunohistochemistry for HRP and lgA. The amount of lgA in the bile also increased in the ID-rats. Immunoblotting after PAGE of the bile revealed the presence of anti-HRP antibody activity. The specific anti-HRP antibody activity in the bile corresponded with secretory lgA. These results indicated that the hepatobiliary system responds to antigenic stimulus by producing specific lgA antibody, and the lymphoid cells localized in the portal triad might serve as the hepatobiliary tract-associated lymphoid tissue, the same as GALT and BALT.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26997","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakauchi, Fumio"}]},{"nameIdentifiers":[{"nameIdentifier":"26998","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoshida, Yutaka"}]},{"nameIdentifiers":[{"nameIdentifier":"26999","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hattori, Atsuo"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.57.485","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂内, 文男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"吉田, 豊"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"服部, 淳夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X575485.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X575485.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14984/files/n0036472X575485.pdf"},"version_id":"9b8761ab-c117-4f65-81ce-c37298d7acda"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bile","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Secretory lgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lymphoid tissue","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatobiliary system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Local immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝, 胆道系における局所免疫機構の解析 : HRPによる総胆管感作ラットでの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝, 胆道系における局所免疫機構の解析 : HRPによる総胆管感作ラットでの検討","subitem_title_language":"ja"},{"subitem_title":"Studies on the Local Immune Mechanism in the Hepatobiliary Tract of the Rat : Immunological Analysis of the Liver and Bile after Retrograde Injection of HRP into the Common Bile Duct","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1719"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14984","relation_version_is_last":true,"title":["肝, 胆道系における局所免疫機構の解析 : HRPによる総胆管感作ラットでの検討"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:33.098481+00:00"}