{"created":"2023-05-15T09:07:34.127143+00:00","id":14981,"links":{},"metadata":{"_buckets":{"deposit":"21da0f81-f9ce-492f-939b-ec9afc2c822b"},"_deposit":{"created_by":14,"id":"14981","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14981"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014981","sets":["1658:1659:1719"]},"author_link":["26983","26982"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"452","bibliographicPageStart":"437","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"During the isolation of carcinoembryonic antigen （CEA） from perchloric acid （PCA） soluble extracts of colonic cancer tissue, an antigen that migrated to α region on immunoelectrophoresis has been previously detected in our laboratory, which we named α-tissue antigen （αTA）. In this study, αTA was found to be antigenically distinct from already known α-globulin components, CEA, nonspecific cross-reacting antigen （NCA）, pregnancy associated proteins, and membrane associated tissular autoantigen （MTA）. αTA was determined as a glycoprotein of 40,000 dalton, pI 3.4 and 11.5% sugar content. Serum αTA level was determined by competitive RIA in 124 healthy controls, 162 patients with neoplastic diseases, and 87 patients with non-neoplastic diseases. The normal upper level of serum αTA was 200 ng/ml, and the incidence of cases with the elevation was found to be 69.1% （112/162） for neoplastic diseases, and 43.7% （38/87） for non-neoplastic diseases. As to neoplastic dieases, the inci-dence of increased levels in patients with solid tumors was higher than in patients with hematopoietic diseases. In addition, the incidence of serum αTA level over 1,000ng/ml was 31.5% （39/124） in patients with solid tumors and 5.3% （2/38） in patients with malignant blood diseases, the former was statistically higher than the latter （p<0.01）. Regarding the relations of serum αTA levels and the stages in 32 cases with gastric cancer, the levels were found to be higher in stage IV than in the other stages （p<0.05）. There was, however, no correlation between the serum levels of αTA and those of CEA. In non-neoplastic diseases, it was notable that 3 of the 5 cases with ulcerative colitis had serum αTA levels over 1,000ng/ml. Immunofluorescence antibody analysis indicated that αTA was located largely on the surface of cancer cells. In signet ring cell carcinoma of the stomach obtained from ascites, αTA was found in the cytoplasm. Only a faint immunofluorescence of αTA was detected in normal and non-cancerous digestive mucosa, and granulocytes and monocytes. In addition, monoclonal antibody （MoAb） TA53 was developed from a fusion of the murine myeloma cell line with splenocytes of BALB/c mice which were immunized with purified αTA. The MoAb reacted with αTA recognized as 40,000 dalton protein of colonic cancer cells but did not react with granulocytes. This MoAb will be expected to develop a more specific assay system for monitoring the serum levels of αTA.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26983","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kobayashi, Takeaki"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.57.437","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 壮光"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X574437.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X574437.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14981/files/n0036472X574437.pdf"},"version_id":"58e384d9-07af-4a90-af63-5a3451e54e77"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-Tissue antigen (αTA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Membrane associated tissular autoantigen (MTA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Carcinoembryonic antigen (CEA)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor associated antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monoclonal antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"大腸癌過塩素酸可溶分画中に検出されたα-tissueantigenの解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌過塩素酸可溶分画中に検出されたα-tissueantigenの解析","subitem_title_language":"ja"},{"subitem_title":"Characterization of α-Tissue Antigen (αTA) Detected in Perchloric Acid Soluble Extracts of Colonic Cancer Tissue","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1719"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14981","relation_version_is_last":true,"title":["大腸癌過塩素酸可溶分画中に検出されたα-tissueantigenの解析"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:32.559276+00:00"}