{"created":"2023-05-15T09:07:33.993661+00:00","id":14979,"links":{},"metadata":{"_buckets":{"deposit":"b23799b1-3b46-4121-aaad-c3260dc1a806"},"_deposit":{"created_by":14,"id":"14979","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14979"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014979","sets":["1658:1659:1719"]},"author_link":["26976","26977","26974","26975"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1988-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"422","bibliographicPageStart":"407","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to clarify the mechanism of hyper-group I pepsinogenemia in patients with gastric or duodenal ulcer （GU or DU）, fasting serum group I pepsinogen （PGI） and changes of PGI levels in serum and of pepsin secretions in gastric juice following various stimulations were studied. Simultaneously, immunoreactive PGI （IR-PGI） concentrations and the number of PGI positive cell in the gastric mucosa were also examined. The results were as follows: 1） Fasting serum PGI levels were higher in the active, healing and scarring stages of GU and DU patients, respectively than those in normal controls （p<0.01）. The levels, however, decreased gradually following the healing of ulcers. 2） In GU and DU patients, serum PGI levels significantly increased following insulin-induced hypoglycemia. The response patterns of serum PGI after insulin-stimulation were roughly classified into three types: fluctuating type （type A）, delayed elevation type （type B） and low response type （type C）. Gastric mucosal manifestations and excessive acid and pepsin secretions in GU and DU patients were often found in type A. In GU patients, serum PGI levels increased after secretin stimulation. However, they did not increase in DU patients. 3） Pepsin output （POP） in gastric juice of normal controls and patients with GU or DU showed significant increase by insulin-induced hypoglycemia. Secretin stimulation markedly increased POP in DU patients as compared with normal controls or GU patients. 4） IR-PGI concentrations and number of IR-PGI positive cell in fundic mucosa obtained by endoscopy or surgery showed a good correlation （r=0.91, p<0.01） and were significantly higher in DU than in GU patients. ?These results suggest that the mechanism involved in hyper-group I pepsinogenemia is different between both ulcers. Namely, the hyper-group I pepsinogenemia in GU patients may be caused relevant to a leakage of PGI from chief cells under breakdown state in the gastric mucosal protection mechanism, whereas in DU patients it may be associated with the marked increase of chief cells.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26976","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujii, Ken"}]},{"nameIdentifiers":[{"nameIdentifier":"26977","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yabana, Tsuyoshi"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.57.407","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤井, 謙"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢花, 剛"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X574407.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X574407.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14979/files/n0036472X574407.pdf"},"version_id":"27671c4c-d91a-4330-8479-b00d0089fdce"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Group I pepsinogen (PGI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PGI cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peptic ulcer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric pepsin secretions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Gastric mucosal protection","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胃および十二指腸潰瘍におけるimmunoreactivegroupIpepsinogen (PGI) の血中動態ならびに胃粘膜組織内分布","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃および十二指腸潰瘍におけるimmunoreactivegroupIpepsinogen (PGI) の血中動態ならびに胃粘膜組織内分布","subitem_title_language":"ja"},{"subitem_title":"Changes in Serum Group I Pepsinogen(PG I) Levels and Distribution of Immunoreactive PG I in Gastric Mucosa in Patients with Gastric or Duodenal Ulcer","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1719"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14979","relation_version_is_last":true,"title":["胃および十二指腸潰瘍におけるimmunoreactivegroupIpepsinogen (PGI) の血中動態ならびに胃粘膜組織内分布"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:32.158925+00:00"}