@article{oai:sapmed.repo.nii.ac.jp:00014956,
 author = {芳村, 裕 and 矢花, 剛},
 issue = {1},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Feb},
 note = {In attempt to clarify the pathogenesis of cysteamine-induced duodenal ulcer in rats, duodenal mucosal blood flow （DMBF） and duodenal mucosal vascular architecture were examined using hydrogen gas clearance method and intra-arterial infusion technique with India ink as a tracer. The effect of pretreatment with secretin, somatostatin, atropine, cimetidine, cetraxate and proglumide on the impaired duodenal microcirculation induced by cysteamine administration was also investigated. The results were as follows; 1） A significant decrease of the DMBF occurred as early as 5 min after cysteamine administration and lasted up to 60 min later, whereas no significant changes in the DMBF were found in the control group treated with saline alone. The dramatical reduction of the DMBF seemed to be in paralell with the degree of the duodenal mucosal alteration with an initial edema caused by cysteamine administration. On the other hand, cysteamine did not exert any influence on the gastric mucosal blood flow （GMBF）. 2） Pretreatment with either secretin, somatostatin, atropine, cimetidine or cetraxate significantly inhibited the reduction of the DMBF induced by cysteamine administration. In any event, these agents appeared to have beneficial effects to prevent the weakness and/or breakdown of the duodenal mucosal protection mechanism, but no similar effect was found in the group pretreated with proglumide, an antigastrin agent. 3） Intraduodenal instillation of 0.1 N HCl did not produce an effect on the DMBF compared with that in the control group with saline administered into the duodenum. 4） Using India ink as a tracer, it was demonstrated that cysteamine induced morphological and functional changes in the duodenal mucosal microcirculation system as an early effect and that these mucosal changes were prevented by pretreatment with secretin or cetraxate. These results strongly suggested that the morphological and functional alterations in the duodenal? mucosal microcirculation system, which is an important mechanism of duodenal mucosal protection, might greatly be associated with the pathogenesis and development in the cysteamine-induced duodenal ulcer.},
 pages = {113--122},
 title = {十二指腸潰瘍の成因に関する実験的研究第1篇 ラットCysteamine潰瘍における十二指腸粘膜微小循環障害について},
 volume = {57},
 year = {1988}
}