{"created":"2023-05-15T09:07:26.160940+00:00","id":14801,"links":{},"metadata":{"_buckets":{"deposit":"1b30ee14-0920-48f9-a17b-d035116cf645"},"_deposit":{"created_by":14,"id":"14801","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14801"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014801","sets":["1658:1659:1720"]},"author_link":["26252","26253","26250","26251"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Model experiments using anti HLA monoclonal antibodies were performed to apply the immune response of anti-idiotypic antibodies to immunotherapy since anti-idiotypic antibodies are of interest in the investigation of a new immunomodulator for cancer patients.Polyclonal anti-idiotypic antisera and anti-idiotypic monoclonal antibodies induced with anti HLA-A2.A28 monoclonal antibody KS1 in a syngeneic system recognized the private idiotype on monoclonal amtibody KS1.Idiotype mapping of monoclonal antibody ES1 showed that there might be at least four idiotopes on it ; two idiotopes at a combining site and another at an intermediate site.The four diffrerent anti-idiotypic monoclonal antibodies might induce anti-anti-idiotypic antibodies specific to their immunized anti-idiotypic monoclonal antibody in the syngeneic system.One of the anti-idiotypic monoclonal antibodies against the idiotope at the combining site of monoclonal antibody KS1could induce an anti-anti-idiotypic antibody which might have the same reactivity as that of monoclonal antibody KS1 to HLA-A2.A28 antigen.The results suggest that an anti-idiotypic antibody bearing the internal image of a tumor associated antigen may induce the anti-anti-idiotypic antibodies specific to the tumor associated antigen and therefore may be useful for cancer therapy.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26252","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsujisaki, Masayuki"}]},{"nameIdentifiers":[{"nameIdentifier":"26253","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Kohzoh"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.58.1","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻崎, 正幸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 浩三"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"n0036472X5811.pdf","filesize":[{"value":"816.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X5811.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14801/files/n0036472X5811.pdf"},"version_id":"88739c2c-f17e-4b81-9faf-93323b6d7df2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anti-idiotypic monoclonal antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Internal image of antigen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiotype mapping","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cancer therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗HLA-A2.A28モノクローナル抗体に対する抗イディオタイプモノクローナル抗体の作製と免疫応答の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗HLA-A2.A28モノクローナル抗体に対する抗イディオタイプモノクローナル抗体の作製と免疫応答の解析","subitem_title_language":"ja"},{"subitem_title":"Preparation and Immune Response of Ant-idiotypic Monoclonal Antibodies to Anti HLA-A2.A28 Monoclonal Antibodies","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-08-16"},"publish_date":"2019-08-16","publish_status":"0","recid":"14801","relation_version_is_last":true,"title":["抗HLA-A2.A28モノクローナル抗体に対する抗イディオタイプモノクローナル抗体の作製と免疫応答の解析"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:25:05.079543+00:00"}