{"created":"2023-05-15T09:07:25.739425+00:00","id":14791,"links":{},"metadata":{"_buckets":{"deposit":"9c5c4937-854e-4bc6-b1c7-73d7dd133008"},"_deposit":{"created_by":14,"id":"14791","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14791"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014791","sets":["1658:1659:1724"]},"author_link":["26192","26193","26194","26189","26190","26191"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"186","bibliographicPageStart":"175","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antigen corresponding to monoclonal antibody （MoAb） AM34, which had been generated from the fusion of mouse myeloma cells with splenocytes obtained from a BALB/c mouse that had been immunized with crude amyloid proteins extracted from the amyloid kidney of a patient with rheumatoid arthritis, was investigated for cDNA cloning by immunoscreening. The amino acid sequence deduced from the nucleotide sequences was then compared with the previously reported ones. It was consequently revealed that the amino acid sequence of the antigen reacted with MoAb AM34 corresponded with the Oterminal site of factor H, which is a complementary co-factor. Western blot analysis followed by immunoprecipitation with MoAb AM34 or anti-factor H poly- clonal antibody revealed that each antibody reacted with the same molecule of 150 KD, suggesting that the AM34 antigen is complement factor H or a very closely related molecule. Immunohistological analysis with MoAb AM34 revealed that the epitope is located in the amyloid deposits resulting from secondary amyloidosis, Alzheimer's disease or Down's syndrome. It is there- fore concluded that factor H or factor H-related protein exists in the above-mentioned amyloid tis- sues.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26192","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ota, Masahiko"}]},{"nameIdentifiers":[{"nameIdentifier":"26193","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Itoh, Fumio"}]},{"nameIdentifiers":[{"nameIdentifier":"26194","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Kohzoh"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.62.175","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"太田, 雅彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊東, 文生"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今井, 浩三"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0036472X623175.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X623175.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14791/files/n0036472X623175.pdf"},"version_id":"a7ed0864-671b-4252-9646-f724a1e4fd70"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cDNA cloning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Factor H","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Factor H-related molecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Alzheimer's disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アミロイド関連分子AM34抗原エピトープの解析と臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミロイド関連分子AM34抗原エピトープの解析と臨床応用","subitem_title_language":"ja"},{"subitem_title":"Analysis of the Epitope of an Amyloid-related Molecule, AM34 Antigen, and Its Clinical Application","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1724"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14791","relation_version_is_last":true,"title":["アミロイド関連分子AM34抗原エピトープの解析と臨床応用"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:23:47.927472+00:00"}