{"created":"2023-05-15T09:07:25.480911+00:00","id":14785,"links":{},"metadata":{"_buckets":{"deposit":"b7e404c7-f1ac-42ef-ba45-7a497fba4aae"},"_deposit":{"created_by":14,"id":"14785","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"14785"},"status":"published"},"_oai":{"id":"oai:sapmed.repo.nii.ac.jp:00014785","sets":["1658:1659:1724"]},"author_link":["26170","26169"],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"11","bibliographicPageStart":"99","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"札幌医学雑誌 = The Sapporo medical journal"},{"bibliographic_title":"The Sapporo medical journal","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study was performed to clarify the neural mechanisms responsible for func- tional recovery of hindlimb movements after thoracic spinal cord injury in rats. The aim was two- fold: 1） to evaluate the possibility of plastic changes such as collateral sprouting from the cor- ticospinal fibers in the remaining cord following thoracic spinal hemisection ; and 2） to determine which descending pathways play the most important roles in the recovery of coordinated movement in chronically spinal-lesioned rats. Left spinal hemisections （HS） or partial spinal lesions sparing only right ventral （VQ） or dorsal quadrant （DQ） of the spinal cord at the lower thoracic （T9-10） level were performed aseptically under Nembutal anesthesia. Coordinated four-legged locomotion reappeared within 2 weeks in HS rats and within 2-3 weeks in VQ rats, respectively, after the initial operations. However, no recovery of hindlimb movement was observed in DQ rats. Motor cortical microstimulation as well as WGA-HRP and biocytin injections into the hindlimb motor cortex was performed in recovered HS rats with survival period of 1-2 months. Motor cor- tical microstimulation on the hemisected side did not show any differences in the thresholds for evok- ing ipsilateral hindlimb EMG responses in recovered HS rats as compared with uninjured controls. There was no significant increase in the numbers of corticospinal fibers crossing from the intact side back to the hemisected side, nor were growth cones present in the lumbar segments. These results showed no evidence for plastic changes of corticospinal fibers at the lumbar segments in HS rats. In terminal experiments for VQ and DQ rats, the right brachial plexus （C6-T1） was dissected and mounted on a bipolar stimulating electrode. Interlimb reflex potentials and spino-bulbo-spinal （SBS） reflex potentials were recorded under Nembutal anesthesia and urethane-chloralose anesthesia, respectively. Threshold intensities for evoking interlimb reflexes from bilateral hindlimb muscles were elevated for a week after the initial operation and returned to the normal range within 2-3 weeks in VQ rats. SBS reflexes from bilateral hindlimb muscles under urethane-chloralose anesthe- sia disappeared for a week after the initial operation and reappeared within 2-3 weeks in VQ rats. On the other hand, the early threshold elevation for interlimb reflexes and the disappearance of SBS reflexes persisted over the one month observation period in DQ rats. These results demonstrated that the propriospinal （interlimb reflex） pathways and reticulospinal （SBS） pathways are essential for the functional recovery of coordinated four-legged locomotion after spinal cord injury in rats.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"26170","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imai, Tomihiro"}]}]},"item_7_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15114/smj.62.99","subitem_identifier_reg_type":"JaLC"}]},"item_7_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"札幌医科大学医学部"}]},"item_7_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-472X","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今井, 富裕"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-31"}],"displaytype":"detail","filename":"n0036472X62299.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"n0036472X62299.pdf","url":"https://sapmed.repo.nii.ac.jp/record/14785/files/n0036472X62299.pdf"},"version_id":"1a5e5982-5be7-4792-8919-323cbd7116fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Spinal injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasticity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Corticospinal tract","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spino-bulbo-spinal reflex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"実験的脊髄傷害後のラット後肢運動機能回復の神経機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"実験的脊髄傷害後のラット後肢運動機能回復の神経機序","subitem_title_language":"ja"},{"subitem_title":"Neural Mechanisms Underlying Functional Recovery of the Hindlimb Movements after Spinal Cord Injury in Rats","subitem_title_language":"en"}]},"item_type_id":"7","owner":"14","path":["1724"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-07-31"},"publish_date":"2019-07-31","publish_status":"0","recid":"14785","relation_version_is_last":true,"title":["実験的脊髄傷害後のラット後肢運動機能回復の神経機序"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-12-13T02:23:46.901470+00:00"}