@article{oai:sapmed.repo.nii.ac.jp:00014757,
 author = {高山, 義一 and 杉山, 敏郎 and 横田, 憲治},
 issue = {2},
 journal = {札幌医学雑誌 = The Sapporo medical journal, The Sapporo medical journal},
 month = {Apr},
 note = {Since the identification and isolation of spiral gram-negative bacterium from the human stomach, the bacterium, renamed Helicobacter pylori （H. pylori）, has been presumed to be a pathogen with an etiologic role in gastritis and peptic ulcer diseases. In this study, we investigat ed H. pylori antibody in the gastric juice of patients with gastro-duodenal diseases, since the local immune response of gastric mucosa might be associated with the pathophysiology of H. pylori infec tion in such diseases. 1） IgA type antibody to H. pylori was predominantly detected in gastric juice and the antibody profile was different from that of the antibody in serum. IgA type antibody to H. pylori possessed a secretory component. In addition, IgA type antibody was preferentially detected in the gastric juice of patients infected with H. pylori rather than non-infected patients. These observations suggest that H. pylori coexists with a specific IgA antibody in gastric juice, although the IgA anti body has a functional form, that is, being a secretory IgA. 2） The titer of IgA type CP3 antibody in gastric juice was correlated with the histological grade of gastritis, suggesting that a local immune response to H. pylori in gastric mucosa might be associat ed with the formation of gastritis. 3） The IgA type H. pylori antibody in gastric juice reacted specifically with H. pylori itself and the antibody was capable of agglutinating H. pylori in vitro, however, in the presence of a rather high concentration of the antibody. Further investigations are required to elucidate whether the IgA type antibody in gastric juice inhibits H. pylori from attaching to and invading the gastric mucosa and from forming colonies in the gastric mucosa.},
 pages = {121--132},
 title = {胃液 Helicobacter Pylori 抗体の慢性胃炎における臨床的意義},
 volume = {61},
 year = {1992}
}